European Journal of Internal Medicine

April 2017

22 Articles

Letter to the Editor

Nephrotoxic potential of proton pump inhibitors

1 April 2017
Author(s): Fizzah Arif

To the Editor,

Is diuretic withdrawal safe in patients with heart failure and reduced ejection fraction? A retrospective analysis of our outpatients cohort

5 April 2017
Author(s): Giuseppe Romano, Giuseppe Vitale, Diego Bellavia, Valentina Agnese, Francesco Clemenza

Although diuretics are essential to optimize volume status in patients with heart failure with reduced ejection fraction (HFrEF) [1], safety and benefits of prolonged diuretic treatment are uncertain... more

Predicting recurrence after a first unprovoked venous thromboembolism: Retrospective validation of the DAMOVES score

6 April 2017
Author(s): A.I. Franco Moreno, M.J. García Navarro, J. Ortiz Sánchez, J.M. Ruiz Giardín

Unprovoked venous thromboembolism (VTE) is associated with a 5 to 27% annual risk of recurrence after discontinuation of anticoagulation (AC) [1–4], and indefinite AC is recommended if the bleeding... more

Prevalence of older in-patients at risk of clopidogrel resistance according to the STIB score. Results from REPOSI registry

11 April 2017
Author(s): Anna Gallotta, Alessandra Marengoni, Luca Pasina, Laura Cortesi, Alessandro Nobili

Clopidogrel and acetylsalicylic acid are cornerstones of treatment of the acute coronary syndromes (ACS) and percutaneous coronary interventions (PCI) [1]. The problem of clopidogrel resistance was... more

Risks of contrast media applied via the gastrointestinal route

14 April 2017
Author(s): Ingrid Boehm, John Morelli, Knud Nairz, Patricia Silva Hasembank Keller, Johannes T. Heverhagen

Diagnostic imaging procedures of the gastrointestinal tract are most commonly performed following administration of contrast media (CM), either enteric, IV, or both. Barium or iodinated CM in concert... more

X-ChEXIT in screening for occult cancer in patients with a deep vein thrombosis

17 April 2017
Author(s): W.T. Moest, C. Kruydenberg, M. Tan, T. Koster

Recently there has been a lot of debate about how extensive the screening for occult cancer in patients with a deep vein thrombosis (DVT) should be. Cornuz et al. was one of the first to suggest that... more

Serum cartilage oligomeric matrix protein levels as a novel non-invasive biomarker for liver fibrosis in patients with chronic viral hepatitis? It is too early

18 April 2017
Author(s): Rui Huang, Juan Xia, Xiaomin Yan, Yong Liu, Chao Wu

We read with great interest the recently published article by Zachou et al., in which they investigated the possible application of serum cartilage oligomeric matrix protein (COMP) levels as a novel... more

Deprescription at hospital discharge: Outcomes of a deprescription promoting campaign

18 April 2017
Author(s): Inmaculada Poquet, Carlos Tornero

Deprescription is the reduction or suspension of drugs that are not necessary or which are potentially harmful — a situation found in up to 19% of all elderly European patients and in up to 46% of... more

The case of homeopathy, “how to search PubMed” may be a first step

20 April 2017
Author(s): Salvatore Corrao, Giuseppe Natoli

We read with great interest your editorial [1]. We have appreciated the question you raised. In our opinion, one of the possible causes of this trouble is the lack of awareness and knowledge of... more

Is abdominal auscultation a still relevant part of the physical examination?

22 April 2017
Author(s): Marco Zuin, Gianluca Rigatelli, Antonella Nadia Andreotti, Luisella Fogato, Loris Roncon

Abdominal auscultation represents a fundamental part of the clinical examination, especially in patients with gastroenterological complainants [1]. However, over the last years, many divergent views... more

C-reactive protein, lipoprotein (a) and cystatin C levels increase with multimorbidity in older persons

23 April 2017
Author(s): Emirena Garrafa, Niccolò Casnici, Flaminio Squazzoni, Daniela Uberti, Alessandra Marengoni

Dear Editor

Prevalence of hyperglycemia and incidence of stress hyperglycemia in hospitalized patients: A retrospective cohort

29 April 2017
Author(s): María Paula Russo, Cristina María Elizondo, Diego Hernán Giunta, María Florencia Grande Ratti

Hospital hyperglycemia (HH), defined as any glycemia value >140mg/dl according the last consensus [1], may occur in people who were previously diagnosed diabetes, as well as in those with... more

Narrative Review

Clinical disorders responsible for plasma hyperviscosity and skin complications

5 April 2017
Author(s): Gregorio Caimi, Melania Carlisi, Caterina Urso, Rosalia Lo Presti, Eugenia Hopps

In this brief review, we have examined some clinical disorders which are associated to an altered hemorheological profile and at times accompanied by skin ulcers. This skin condition may be, in fact... more

A decade of progress on the genetic basis of coronary artery disease. Practical insights for the internist

7 April 2017
Author(s): Domenico Girelli, Chiara Piubelli, Nicola Martinelli, Roberto Corrocher, Oliviero Olivieri

Clinicians are well aware of the importance of a positive family history for coronary artery disease (CAD). Nonetheless, elucidation of the genetic basis of CAD has long proven difficult. The... more

Original Article

The “Ulysses syndrome”: An eponym identifies a psychosomatic disorder in modern migrants

1 April 2017
Author(s): Raffaella Bianucci, Philippe Charlier, Antonio Perciaccante, Donatella Lippi, Otto Appenzeller

Due to civil wars, violence and persecutions, between 2015 and 2016, more than 1.4 million people, from the Middle East and Africa, fled their counties and migrated to Europe. The vast majority of... more

Non-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977–2015)

4 April 2017
Author(s): Pedro Iglesias, Karina Arcano, Vanessa Triviño, Paula García-Sancho, Juan José Díez, Fernando Cordido, Carles Villabona

To assess clinical features, diagnostic procedures, therapies and outcomes in patients with clinically non-functioning pituitary adenomas (NFPAs) surgically treated over the last four decades.

Length of stay and risk of very early readmission in acute heart failure

8 April 2017
Author(s): Gema Miñana, Maria José Bosch, Eduardo Núñez, Anna Mollar, Enrique Santas, Ernesto Valero, Sergio García-Blas, Mauricio Pellicer, Vicent Bodí, Francisco J. Chorro, Juan Sanchis, Julio Núñez

In patients admitted for acute heart failure (AHF), optimal length of stay (LOS) remains controversial. Longer hospitalizations are associated with worse prognosis, but little is known about short... more

Comparison of coronary artery bypass grafting and drug-eluting stents in patients with chronic kidney disease and multivessel disease: A meta-analysis

8 April 2017
Author(s): Yushu Wang, Sui Zhu, Peijuan Gao, Qing Zhang

The optimal revascularization strategy of coronary artery bypass grafting (CABG) versus percutaneous coronary intervention with drug-eluting stent (PCI-DES) in patients with chronic kidney disease (... more

Fitness Fatness Index and Alzheimer-specific mortality

22 April 2017
Author(s): Emily Frith, Paul D. Loprinzi

We evaluated the specific association between a Fitness Fat Index (FFI) and Alzheimer's-specific mortality among a national sample of the broader U.S. adult population.

Reflections in Internal Medicine

Error, contradiction and reversal in science and medicine

11 April 2017
Author(s): Sergio Coccheri

Error and contradictions are not “per se” detrimental in science and medicine. Going back to the history of philosophy, Sir Francis Bacon stated that “truth emerges more readily from error than from... more

Review Article

Genetics of common complex diseases: a view from Iceland

20 April 2017
Author(s): David O. Arnar, Runolfur Palsson

In the past decade, large scale genotyping has led to discoveries of numerous sequence variants that confer increased risk of many common complex diseases. Interestingly, a substantial proportion of... more