Diagnostic imaging procedures of the gastrointestinal tract are most commonly performed following administration of contrast media (CM), either enteric, IV, or both. Barium or iodinated CM in concert with X-ray based imaging modalities and gadolinium-based contrast agents (GBCA) for magnetic resonance imaging are frequently utilized to improve delineation of the gastrointestinal tract. Based on previously published data, iodinated CM are utilized for an estimated >100 million procedures and GBCA for an estimated >30 million procedures worldwide every year [1–4].