April 2020

36 Articles

No Section

The quality of the reported sample size calculation in clinical trials on COVID-19 patients indexed in PubMed

29 April 2020
Author(s): Paul H. Lee

Given the utmost priority of COVID-19 research, many medical journals, especially the leading ones, expedited the review process of these papers. It was expected that the amount of submitted papers... more


Risk stratification vs routine intensive care stay in non ST segment elevation myocardial infarction (NSTEMI)

13 April 2020
Author(s): Stefano Savonitto, Nuccia Morici

Non-ST-segment-elevation acute coronary syndromes (NSTE ACS) encompass a wide spectrum of clinical conditions characterised by acute ischemic symptoms, electrocardiographic signs of myocardial... more

Alcohol intake and atrial fibrillation: A new topic in gender medicine

20 April 2020
Author(s): Fabio Angeli, Roberto De Ponti, Paolo Verdecchia

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and a major risk factor for stroke, heart failure, hospitalization and mortality [1–3]. It affects... more

Prolyl-hydroxylase domain inhibitors in chronic kidney disease, a promising alternative for erythropoiesis-stimulating agent

20 April 2020
Author(s): A. Rubinsztajn, D. Fouque

Anemia is one of the most common complications during chronic kidney disease (CKD) and results from a progressive lack of erythropoietin (EPO). EPO plays a major role in erythropoiesis by inducing... more

Letter to the Editor

Validation of hemolytic anemia discharge diagnosis codes in the French hospital database

24 April 2020
Author(s): Julien Maquet, Hélène Derumeaux, Maryse Lapeyre-Mestre, Laurent Sailler, Guillaume Moulis

Hemolytic anemia (HA) is a group of rare diseases that can be congenital such as thalassemia, sickle-cell anemia, enzyme-deficiency hemolytic anemia and spherocytosis, or acquired such as autoimmune... more

Non-SARS CoV2 positive critical patients: sons of a lesser God?

28 April 2020
Author(s): Giovanni Gulli

As the number of confirmed cases of coronavirus in Italy continues to rise, the reorganization of the hospitals outlined by Grasselli et Al. [1] across the country made wards slowly emptied, elective... more

Reorganizing Italian Internal Medicine wards for COVID 19

29 April 2020
Author(s): Antonino Mazzone, Nicola Mumoli

most of the Internal Medicine wards in the Lombardy hospitals, have beens almost completely reorganized to accommodate the management of patients with COVID-19. Analysis of the data coming from... more

Is low sodium intake a risk factor for severe and fatal COVID-19 infection?

7 April 2020
Author(s): Adrian Post, Robin P.F. Dullaart, Stephan J.L. Bakker

As of March 16th, the number of deaths due to the coronavirus 2019 (COVID-19) outside China has surpassed those in China. Intriguingly, recent calculations that adjust for an incubation period of up... more

Covid-19 cases in a no-Covid-19 geriatric acute care setting. A sporadic occurrence?

29 April 2020
Author(s): Stefano Fumagalli, Bernardo Salani, Luciano Gabbani, Enrico Mossello, Andrea Ungar

The pandemic outbreaks of coronarovirus disease 2019 (Covid-19) is associated to a higher risk of complications and mortality in older patients because of their greater complexity and the frequent... more

“Haven't I always been a sickly person?” Controversies about L. van Beethoven's illnesses

10 April 2020
Author(s): Renato Fellin, Jürgen Richert

The life of this exceptional genius (1770–1827), was embittered by progressive hearing loss which he experienced at an early age and undoubtedly caused him very severe suffering and had a hard effect... more


13 April 2020
Author(s): Giovanni de Simone, Costantino Mancusi

On March 23, 2020, the Bergamo Hospital team, one of the most challenged teams fighting against COVID-19 web-broadcasted a 1-hour conference on the state of their experience, seeking for discussion... more

Prognostic value of adiponectin in patients with stable coronary artery disease in the era of statins

29 April 2020
Author(s): Loukianos S Rallidis, Andreas Katsimardos, Nikolaos Kosmas, Taxiarchoula Rallidi, Antonia Kountouri

Adiponectin is a circulating cytokine produced by the adipose tissue. Experimental data suggest that adiponectin exerts beneficial effects on insulin sensitivity, chronic low-grade inflammation,... more

Comparative prediction of long-term mortality by the CHA2DS2-VASc score and cardiac troponin I levels in patients with atrial fibrillation at the emergency department

14 April 2020
Author(s): Maribel González-del-Hoyo, Anna Carrasquer, Gil Bonet, Isabel Fort-Gallifa, Alfredo Bardají

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice, and is associated with an increased risk of stroke, heart failure (HF) and mortality [1]. In this regard, the CHA2DS2-VASc... more

The Impact Of Diabetes Mellitus And Microvascular Complications On Heart Failure Biomarkers

15 April 2020
Author(s): Florina Frîngu, Dumitru Zdrenghea, Raluca Tomoaia, Alexandra Dădârlat-Pop, Dana Pop

The presence of diabetes mellitus (DM) in patients with cardiovascular disease is associated with a greater number of major adverse events [1]. One of the most severe consequences is represented by... more

Comparison of stroke recurrence between antiplatelet and closure therapy in cryptogenic stroke patients with patent foramen ovale and its influencing factors

16 April 2020
Author(s): Chuanjing Zhang, Liangrong Zheng, Yanxing Zhang, Hangyuan Guo, Jufang Chi

Stroke is the second highest disease causing burden on the global economy and one of the leading causes of non-traumatic disability [1]. As many as 30–40% of ischemic stroke cases have no identified... more

Clinical trials: generalizability is much more than representativeness

18 April 2020
Author(s): Rafael Dal-Ré

Recently, Anderson et al [1] reported on the generalizability of trials supporting the 2017 American College of Cardiology/American Heart Association blood pressure guideline. They are correct when... more

Guideline directed low-density lipoprotein cholesterol goal achievement: A real-world study from a cardiology ward

21 April 2020
Author(s): Haiyang Gao, Chenguang Yang, Jiefu Yang, Fang Wang

This manuscript has been thoroughly edited by a native English speaker from an editing company. Editing Certificate will be provided upon request.

SARS-CoV-2 detection in the pericardial fluid of a patient with cardiac tamponade

22 April 2020
Author(s): Andrea Farina, Giuseppe Uccello, Marta Spreafico, Giorgio Bassanelli, Stefano Savonitto

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus first identified in Wuhan, China, at the end of 2019. Since then it has caused more than 1,700,000 confirmed cases... more

Factors associated with mortality in patients with COVID-19. A quantitative evidence synthesis of clinical and laboratory data

22 April 2020
Author(s): Paulo Ricardo Martins-Filho, Carolina Santos Souza Tavares, Victor Santana Santos

The COVID-19 pandemic caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) has become a serious challenge for health systems worldwide. Despite the favorable clinical course for most... more

Smoking Habit and Hospitalization for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Related Pneumonia: the unsolved paradox behind the evidence.

22 April 2020
Author(s): Giovanna Garufi, Luisa Carbognin, Armando Orlandi, Giampaolo Tortora, Emilio Bria

Since the beginning of the SARS-CoV-2 pandemic earthquake (more than 1.8 million infected subjects worldwide as of mid-April), differences across countries with regard to hospitalization and death... more

HIV Testing In Patients Diagnosed With Community Acquired Pneumonia Or Primary Lung Cancer From 2014 To 2018 In A Teaching Hospital In Spain

23 April 2020
Author(s): Joao Luis Modesto Dos Santos, Aitziber Aguinaga Perez, María Eransus Garzarón, Marta Adelantado Lacasa, Carmen Martín Salas, Julio Sánchez Alvarez

Human immunodeficiency virus (HIV) is one of the most frequent causes of acquired immunodepression. The World Health Organization intends to diagnose 90% of HIV infected patients until 2020 (1),... more

Original Article

Non-adherence to antimicrobial guidelines in patients with bloodstream infection visiting the emergency department

24 April 2020
Author(s): Romy Schuttevaer, Anniek Brink, Jelmer Alsma, Willian van Dijk, Damian C. Melles, Jurriaan E.M. de Steenwinkel, Hester F. Lingsma, Annelies Verbon, Stephanie C.E. Schuit

Bacterial infections can result in considerable mortality and have a profound global burden [1–3]. Patients with a severe infection (e.g. sepsis) often present in an acute care setting, such as the... more

Influence of sex on long-term prognosis in patients with atrial fibrillation treated with oral anticoagulants. Results from the prospective, nationwide FANTASIIA study

14 April 2020
Author(s): Inmaculada Roldán Rabadán, María Asunción Esteve-Pastor, Manuel Anguita Sánchez, Javier Muñiz, Martín Ruiz Ortiz, Francisco Marín, Vanessa Roldán, María Angustias Quesada, José Camacho Siles, Angel Cequier Fillat, Vicente Bertomeu Martinez, Manuel Martínez Sellés, Lina Badimón, FANTASIIA Study Investigators

Atrial fibrillation (AF) is the most frequently cardiac arrhythmia in developed countries [1] and several studies have been described that in both developed and developing countries, the age-adjusted... more

Inappropriate use of carbapenems in an internal medicine ward: Impact of a carbapenem-focused antimicrobial stewardship program

14 April 2020
Author(s): Antonio Faraone, Alice Poggi, Chiara Cappugi, Lorenzo Tofani, Eleonora Riccobono, Tommaso Giani, Alberto Fortini

Carbapenems are last-line beta-lactamic antibiotics used for the treatment of critically ill patients with confirmed or suspected infections involving multidrug-resistant (MDR) bacteria [1]. These... more

Serial investigation of Angiotensin-Converting Enzyme in sarcoidosis patients treated with Angiotensin-Converting Enzyme Inhibitor

16 April 2020
Author(s): Miriana d'Alessandro, Laura Bergantini, Anna Perrone, Paolo Cameli, Matteo Cameli, Antje Prasse, Dario Plataroti, Piersante Sestini, Elena Bargagli

Sarcoidosis is a systemic granulomatous disease associated with T lymphocyte and macrophage activation and migration into affected organs. The interaction between antigens and antigen-presenting... more

The discriminatory power of bleeding assessment tools in adult patients with a mild to moderate bleeding tendency

18 April 2020
Author(s): Johanna Gebhart, Stefanie Hofer, Alexandra Kaider, Judit Rejtö, Cihan Ay, Ingrid Pabinger

Receiver operating characteristic curves for the prediction of any diagnosis of a bleeding disorder by 2 different bleeding assessment tools (Vicenza BAT and ISTH BAT).

Heart rate as an independent predictor of long term mortality of acute heart failure patients in sinus rhythm according to their ejection fraction: data from the AHEAD registry

18 April 2020
Author(s): Jiri Jarkovsky, Jindrich Spinar, Benoit Tyl, Françoise Fougerousse, Jiri Vitovec, Ales Linhart, Petr Widimsky, Roman Miklik, Lenka Spinarova, Jan Belohlavek, Filip Malek, Marian Felsoci, Jiri Kettner, Petr Ostadal, Jan Vaclavik, Ladislav Dusek, Petr Lokaj, Alexandre Mebazaa, Alain Cohen Solal, Jiri Parenica, AHEAD group-authors

Heart failure (HF) is a leading cause of recurrent hospitalization [1,2]. Current European Society of Cardiology (ESC) Guidelines define HF with reduced EF (HFrEF) as HF with EF 

Coffee Consumption is Associated with a Decreased Risk of Incident Chronic Kidney Disease: A Systematic Review and Meta-analysis of Cohort Studies

18 April 2020
Author(s): Thatsaphan Srithongkul, Patompong Ungprasert

Coffee is a popular beverage that is consumed in every corner of the world. It has been estimated that at least 50 percent of adults in the United States drink coffee on a regular basis [1]. With its... more


18 April 2020
Author(s): Valentina Scheggi, Bruno Alterini, Iacopo Olivotto, Stefano Del Pace, Nicola Zoppetti, Benedetta Tomberli, Filippo Bartalesi, Lorenzo Brandi, Nicole Ceschia, Valentina Andrei, Lorenzo Roberto Suardi, Niccolò Marchionni, Pier Luigi Stefàno

Infective endocarditis (IE) is a severe condition, with elevated in-hospital mortality and morbidity due to complications such as acute heart failure and embolic events, the latter largely involving... more

National trends in mechanical ventilation among patients hospitalized with heart failure: a population-based study in Spain (2001-2017)

20 April 2020
Author(s): Javier de Miguel-Díez, Rodrigo Jiménez-García, Manuel Méndez-Bailón, Nuria Muñoz-Rivas, Valentin Hernández-Barrera, Luis Puente-Maestu, José M. de Miguel-Yanes, Napoleón Perez-Farinos, Ana López-de-Andrés

Heart failure (HF) affects around 10% of population over 70 years in developed countries [1]. Despite advances in therapy, it remains a leading cause of hospitalization, morbidity and mortality [2].

Clinical phenotypes and prediction of chronicity in sarcoidosis using cluster analysis in a prospective cohort of 694 patients

21 April 2020
Author(s): Manuel Rubio-Rivas, Xavier Corbella

Sarcoidosis is a multisystem granulomatous disease with high variability and sometimes unpredictable behavior. This great variability necessitates the search for clinical patterns of observed... more

Review Article

Antisense lipoprotein[a] therapy: State-of-the-art and future perspectives

24 April 2020
Author(s): Giuseppe Lippi, Emmanuel J. Favaloro, Fabian Sanchis-Gomar

Lipoprotein[a] (Lp[a]) is an enigmatic low density lipoprotein (LDL)-like particle, in which apolipoprotein B100 (apoB100), the main protein moiety of LDL, is covalently linked through a single... more

The challenge of implementing Less is More medicine: A European perspective

15 April 2020
Author(s): Omar Kherad, Nathan Peiffer-Smadja, Lina Karlafti, Margus Lember, Nathalie Van Aerde, Orvar Gunnarsson, Cristian Baicus, Miguel Bigotte Vieira, António Vaz-Carneiro, Antonio Brucato, Ivica Lazurova, Wiktoria Leśniak, Thomas Hanslik, Stephen Hewitt, Eleni Papanicolaou, Olga Boeva, Dror Dicker, Biljana Ivanovska, Pinar Yldiz, Patrick Lacor, Mark Cranston, Frauke Weidanz, Giorgio Costantino, Nicola Montano

Healthcare systems in developed countries are facing new challenges that include defining the values, objectives and tasks of sustainable medicine. Near universal access to quality health care is one... more

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

20 April 2020
Author(s): Paolo Verdecchia, Claudio Cavallini, Antonio Spanevello, Fabio Angeli

Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are ubiquitous and widely expressed in... more

sLetter to the Editor

Acute hemolysis by hydroxycloroquine was observed in G6PD-deficient patient with severe COVD-19 related lung injury

20 April 2020
Author(s): Lucia De Franceschi, Enrico Costa, Francesco Dima, Matteo Morandi, Oliviero Olivieri

The coronavirus disease COVID19 is a global health pandemic emergency. The disease, named coronavirus disease 2019 (COVID-19) by the WHO, presents symptoms that range from mild to severe and fatal... more

Relevant EFIM Publications

The challenge of implementing Less is More medicine: A European perspective

Author(s): Omar Kherad, Nathan Peiffer-Smadja, Lina Karlafti, Margus Lember, Nathalie Van Aerde, Orvar Gunnarsson, Cristian Baicus, Miguel Bigotte Vieira, António Vaz-Carneiro, Antonio Brucato, Ivica Lazurova, Wiktoria Leśniak, Thomas Hanslik, Stephen Hewitt, Eleni Papanicolaou, Olga Boeva, Dror Dicker, Biljana Ivanovska, Pinar Yldiz, Patrick Lacor, Mark Cranston, Frauke Weidanz, Giorgio Costantino, Nicola Montano
Date:16 April 2020

Medical and surgical co-management – A strategy of improving the quality and outcomes of perioperative care

Author(s): Carmen Fierbinţeanu-Braticevicia, Matthias Raspeb, Alin Liviu Predac, Evija Livčāned, Leonid Lazebnike, Soňa Kiňováf, Evert- Jan de Kruijfg, Radovan Hojsh, Thomas Hansliki, Mine Durusu-Tanrioverj, Francesco Dentalik, Xavier Corbellal, Pietro Castellinom, Monica Bivoln, Stefano Bassettio, Vasco Barretop, Eduardo Montero Ruizq, Luis Camposr, The Working Group on Professional Issues and Quality of Care of the European Federation of Internal Medicine (EFIM)
Date:15 November 2018

Hospital ambulatory medicine: A leading strategy for Internal Medicine in Europe

Author(s): Xavier Corbellaa, Vasco Barretob, Stefano Bassettic, Monica Bivold, Pietro Castellinoe, Evert-Jan de Kruijff, Francesco Dentalig, Mine Durusu-Tanriöverh, Carmen Fierbinţeanu-Braticevicii, Thomas Hanslikj, Radovan Hojsk, Soňa Kiňovál, Leonid Lazebnikm, Evija Livčānen, Matthias Raspeo, Luis Camposp, The Working Group on Professional Issues and Quality of Care, European Federation of Internal Medicine (EFIM)
Date:14 April 2018

More publications

What is EFIM?

The principal objectives of EFIM is to promote internal medicine on a scientific educational, ethical and professional level and to support internists in providing better care for patients throughout Europe.

Learn more

What is internal medicine?

The specialty of internal medicine covers a wide range of conditions affecting the internal organs of the body. Although some diseases specifically affect individual organs, the majority of common diseases. The internist must then be trained to recognise and manage a broad range of diseases and, with the aging population, many patients with chronic and multiple disorders.

Learn more

Internal Medicine meets Public

Under construction.

Coronavirus disease 2019 : short notice for public
Watch our webinars