“From father to son”: Early onset gout in Guidobaldo I da Montefeltro, Duke of Urbino (1472–1508)

Published: 4 August 2016
Author(s): R. Bianucci, A. Perciaccante, O. Appenzeller
Issue: August 2016
Section: Letter to the Editor

Named the “Disease of the Kings”, gout (podagra) is one of the oldest diseases reported in medical literature and has modern clinical relevance due to its impact on morbidity and premature mortality [1,2]. The peak age of onset of gout is in the fourth to sixth decade of life with a strong male predilection [3]. The risk of gout is higher in people with a family history; however the existence of many risk factors (such as male gender, increasing age, obesity, chronic renal impairment, hypertension (metabolic syndrome) and certain diets with high purine i.e.