Associations of proton pump inhibitors and hospitalization due to hyponatremia: A population–based case–control study

Published: 25 August 2018
Author(s): Henrik Falhammar, Jonatan D. Lindh, Jan Calissendorff, Jakob Skov, David Nathanson, Buster Mannheimer
Issue: August 2018
Section: Original Article

Small observational studies and case reports have indicated that proton pump inhibitors (PPIs) may cause hyponatremia. Whether there is a difference between the individual PPIs is yet unknown. Since PPIs are one of the most commonly prescribed groups of drugs, even a rare adverse reaction may have large implications. The objective was to study the association between PPIs and hospitalization due to hyponatremia.