3P association (3PAs): Pituitary adenoma and pheochromocytoma/paraganglioma. A heterogeneous clinical syndrome associated with different gene mutations

Published: 17 August 2019
Author(s): Fernando Guerrero-Pérez, Carmen Fajardo, Elena Torres Vela, Olga Giménez-Palop, Arturo Lisbona Gil, Tomas Martín, Natividad González, Juan José Díez, Pedro Iglesias, Mercedes Robledo, Carles Villabona
Issue: August 2019
Section: Original Article

Pituitary adenomas (PA) associated with pheochromocytomas/paragangliomas (Pheo/PGL), also known as “the three P association” or “3PAs” could be the results of coincidence, but new evidence supports a common pathogenic mechanism in some patients. Our aim is to report the clinical data, surgical outcome, genetic findings of a large case series and review the current knowledge on this topic.