Serum 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage, is associated with mortality independent of inflammation in chronic kidney disease

Published: 9 August 2019
Author(s): Lu Dai, Makoto Watanabe, Abdul Rashid Qureshi, Hideyuki Mukai, Anna Machowska, Olof Heimbürger, Peter Barany, Bengt Lindholm, Peter Stenvinkel
Issue: August 2019
Section: Original Article

Oxidative stress and low-grade systemic inflammation are common interrelated sequelae of chronic kidney disease (CKD) that associate with mortality. We investigated the association of serum 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, with mortality in CKD individuals and analyzed whether inflammation modifies the association.