Tramadol- and codeine-induced severe hyponatremia: A Swedish population-based case-control study

Published: 12 August 2019
Author(s): Henrik Falhammar, Jan Calissendorff, Jakob Skov, David Nathanson, Jonatan D. Lindh, Buster Mannheimer
Issue: August 2019
Section: Original Article

Although tramadol and codeine occasionally have been reported to cause hyponatremia the evidence is scarce. The objective of this investigation was to study the association between weak opioids (tramadol and codeine) and hospitalization due to hyponatremia.