Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults

Published: 9 January 2016
Author(s): Leyre Riancho-Zarrabeitia, Mayte García-Unzueta, Jair A. Tenorio, Juan A. Gómez-Gerique, Víctor L. Ruiz Pérez, Karen E. Heath, Pablo Lapunzina, José A. Riancho
Issue: January 2016
Section: Original Article

Low serum levels of alkaline phosphatase (ALP) are a hallmark of hypophosphatasia. However, the clinical significance and the underlying genetics of low ALP in unselected populations are unclear.