I have read the letter of Marcucci [1] with great attention. First of all, It could be useful to underline that the criticized paper is an editorial, not surprisingly written by an editor, and, in particular, an interview as explicitly stated. It dealt with an important systematic review and meta-analysis of clinical trials of sublingual immunotherapy for grass pollen allergy [2], published in one of the leading journals of medicine. The editor of JAMA himself had thrown a “caveat emptor” [3], just after having published and pointed out the results of the meta-analysis above mentioned.