Aging of the endocrine system and its potential impact on sarcopenia

Published: 30 July 2016
Author(s): Giovanni Vitale, Matteo Cesari, Daniela Mari
Issue: July 2016
Section: Narrative Review

Sarcopenia, occurring as a primary consequence of aging, is a progressive generalized decline of skeletal muscle mass, strength and function. The pathophysiology of sarcopenia is complex and multifactorial. One major cause of muscle mass and strength loss with aging appears to be the alteration in hormonal networks involved in the inflammatory processes, muscle regeneration and protein synthesis.This review describes the recent findings concerning the role of the aging on the endocrine system in the development of sarcopenia.