Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival

Published: 7 July 2016
Author(s): Mehmet Kanbay, Baris Afsar, Dimitrie Siriopol, Hilmi Umut Unal, Murat Karaman, Mutlu Saglam, Mustafa Gezer, Ahmet Taş, Tayfun Eyileten, Ahmet Kerem Guler, İbrahim Aydin, Yusuf Oguz, Kayhan Tarim, Adrian Covic, Mahmut Ilker Yilmaz
Issue: July 2016
Section: Original article

Endostatin, generated from collagen XVIII, and endorepellin, possess dual activity as modifiers of both angiogenesis and endothelial cell autophagy. Plasma endostatin levels are elevated in a large number of diseases, and may reflect endothelial cell dysfunction. Few data on endostatins are available for patients with chronic kidney disease (CKD). We tested whether serum endostatin values are predictive for all-cause mortality and cardiovascular events (CVEs) in a CKD population.