Blood eosinophils as biomarkers of therapeutic response to chronic obstructive pulmonary disease: Still work in progress

Published: 12 July 2019
Author(s): Salvatore Fuschillo, Antonio Molino, Cristiana Stellato, Andrea Motta, Mauro Maniscalco
Issue: July 2019
Section: Review Article

Disease phenotyping is a key step towards an increasingly personalized approach to chronic obstructive pulmonary disease (COPD), leading to a more precise assessment, treatment and definition of disease outcomes.The search for biomarkers able to guide the identification of COPD phenotypes are of great importance for both researchers and clinicians. However, while several biomarkers of inflammation [e.g., peripheral blood eosinophils and fractional expired nitric oxide] have been identified and applied in asthma, none has been successfully linked to discrete clinical parameters of COPD such as exacerbations, natural progression, and treatment response or mortality risk.