Cardiac amyloidosis: An underdiagnosed/underappreciated disease

Published: 30 July 2019
Author(s): Antonis S. Manolis, Antonis A. Manolis, Theodora A. Manolis, Helen Melita
Issue: July 2019
Section: Review Article

Cardiac amyloidosis or amyloid cardiomyopathy (ACM), commonly resulting from extracellular deposition of amyloid fibrils consisted of misfolded immunoglobulin light chain (AL) or transthyretin (TTR) protein, is an underestimated cause of heart failure and cardiac arrhythmias. Among the three types of cardiac amyloidosis (wild-type or familial TTR and light-chain), the wild-type (Wt) TTR-related amyloidosis (ATTR) is an increasingly recognized cause of heart failure with preserved ejection fraction (HFpEF), and amyloidosis should be considered in the differential diagnosis of this heart failure group of patients.