Acute Physiology And Chronic Health Evaluation-2 (APACHE II) and Simplified Acute Physiology Score II (SAPS2) have been developed to assess the risk stratification of patients admitted to the intensive care unit (ICU) and are most commonly used so far. More recently, other simplified scores were tested including the Model for End-Stage Liver Disease (MELD), primarily developed in patients affected by liver disease [1], but subsequently validated as a marker of liver and kidney failure in subjects with multi-organ failure [2].
