The quality of the reported sample size calculations in randomized controlled trials indexed in PubMed

Published: 18 October 2016
Author(s): Paul H. Lee, Andy C.Y. Tse
Issue: October 2016
Section: Original Article

There are limited data on the quality of reporting of information essential for replication of the calculation as well as the accuracy of the sample size calculation. We examine the current quality of reporting of the sample size calculation in randomized controlled trials (RCTs) published in PubMed and to examine the variation in reporting across study design, study characteristics, and journal impact factor. We also reviewed the targeted sample size reported in trial registries.