Potential drug–drug interactions (pDDIs) are critical issues in the management of the elderly. The development of multiple diseases with increasing age leads to therapies based upon many concomitant drugs, a risk factor for severe pDDIs [1]. Pharmacological interactions may affect patient health by leading to adverse drug reactions and more hospitalisations [2–4], so that they also represent a cost for the healthcare systems [5]. In order to minimise pDDIs and assist clinicians with information readily available at the time of prescription, the computerised prescription support system (CPSS) INTERCheck® was developed by the IRCCS Istituto di Ricerche Mario Negri of Milan.
