Published: 17 July 2021
Author(s): Catia Martins
Section: Letter to the Editor

I have read with much interest the narrative review by Busetto and colleagues entitled “Mechanisms of weight regain”, recently published in your journal [1]. There is no doubt that relapse in obesity treatment remains the main challenge in obesity management. Unfortunately, its etiology remains elusive and opposite to the authors` views there is no evidence supporting a role for compensatory biological mechanisms at the level of the homeostatic appetite control system or energy expenditure in this process.

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