Published: 11 April 2022
Author(s): Udhayvir Singh Grewal, Shiva Jashwanth Gaddam, Sahith Reddy Thotamgari, Tyiesha Brown, Kavitha Beedupalli, Glenn Morris Mills
Issue: June 2022
Section: Letter to the Editor

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Patients with HIT present with a decline in platelet count following heparin exposure and may or may not have thrombosis or hemorrhage. About as high as one-half of the cases of HIT are complicated by venous and/or arterial thrombosis which may be limb- or life-threatening [1]. Morbidity in these patients is further increased by bleeding (∼x223C40%) associated with the use of potent non-heparin anticoagulants [2].

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