Brain-kidney cross-talk: Definition and emerging evidence

Published: 13 August 2016
Author(s): Baris Afsar, Alan A. Sag, Can Ege Yalcin, Eren Kaya, Dimitrie Siriopol, David Goldsmith, Adrian Covic, Mehmet Kanbay
Issue: August 2016
Section: Review Article

Cross-talk is broadly defined as endogenous homeostatic signaling between vital organs such as the heart, kidneys and brain. Kidney–brain cross-talk remains an area with excitingly few publications despite its purported clinical relevance in the management of currently undertreated conditions such as resistant hypertension. Therefore, this review aims to establish an organ-specific definition for kidney–brain cross-talk and review the available and forthcoming literature on this topic.