Anti-PD1 therapy-associated cutaneous leucocytoclastic vasculitis: A case series

Published: 1 August 2018
Author(s): Alessandro Tomelleri, Corrado Campochiaro, Giacomo De Luca, Giulio Cavalli, Lorenzo Dagna
Issue: August 2018
Section: Letter to the Editor

Immune-checkpoint inhibitors (ICIs) have shown remarkable efficacy in multiple cancer types [1]. However, these therapies may lead to immune-related adverse events (irAEs) as they promote immune stimulation or interfere with immune tolerance [2]. irAEs include both systemic and organ-specific toxicities (mostly, hypophysitis, colitis, hepatitis, and pneumonitis). Vasculitis, although representing a rare irAE, is one of the most intriguing one as its presentation can be extremely heterogeneous [3, 4] and can be easily misdiagnosed.