European Journal of Internal Medicine

February 2016

28 Articles

Editorial

Sharing data of clinical trials

26 February 2016
Author(s): P.M. Mannucci

The International Committee of Medical Journal Editors (ICMJE) includes a number of editors of general medical journals who first met in 1978 in Vancouver (Canada) with the goal to establish common... more

Internal Medicine Flashcard

Cavity with ball-in-hole lesion in the lung

9 February 2016
Author(s): Yu-Chao Lin, Shuo-Chueh Chen

A 35-year-old male suffered from a cough with sputum for one month. He was relatively healthy in the past and had a smoking history of 0.5 PPD for more than 10years. There was no fever, no dyspnea,... more

Headache and hand numbness in a young female

10 February 2016
Author(s): Prakash R. Paliwal, Vijay K. Sharma

A 21-year-old female presented with complaints of slowly progressive numbness and paresthesia of both hands for the past 4months. She reported no diurnal variations in hand symptoms, relationship of... more

Flashcard: An unusual adverse reaction to iodine-based contrast agent

18 February 2016
Author(s): Mirta Menegatti, Mario Pirisi, Mattia Bellan

A 70-year-old woman was admitted to the Internal Medicine Division of an academic hospital because of persistent fever. She had a history of follicular lymphoma, diagnosed in 2001 and since then... more

Transient ST-segment elevation during acute pancreatitis

20 February 2016
Author(s): Ehab El-Khabiry, Hesham R. Omar, Enrico M. Camporesi

A 27-year-old-woman with history of insulin dependent diabetes mellitus, hypertriglyceridemia and recent laparoscopic cholecystectomy presented to the hospital with severe upper abdominal pain.... more

Acute right iliac fossa pain: Beyond appendicitis

20 February 2016
Author(s): Daniel Romeu Vilar, Daniel López Rey

78years old woman with long-standing metabolic syndromewent to the ED because of abdominal pain located in the right iliac fossa. She did not report alterations in bowel habits, diarrhea, macroscopic... more

Iron deficiency anemia with mucocutaneous lesions

22 February 2016
Author(s): Abhishek Maiti, Avash Das, Debjit Saha

A 56-year-old man presented with fatigue and exertional dyspnea for 2weeks, and few episodes of black tarry stools over the last 1month. The patient endorsed recurrent episodes of epistaxis since his... more

Macroglossia and periorbital ecchymosis

21 February 2016
Author(s): Nely Mercy Díaz Mejía, Eduardo Josué Flores Umanzor, Gala Caixal

A 70-year-old woman with past medical history of idiopathic adult hydrocephalus syndrome was admitted to our center due to malaise of one year of evolution without any other symptomatology.... more

Headache in a patient with renal cell carcinoma.

21 February 2016
Author(s): Vivek Subbiah, Abhishek Maiti

A 52-year-old woman with hypothyroidism and advanced renal cell carcinoma presented with new onset headache, worsening fatigue, and weakness for two weeks. Two years back she developed flank pain,... more

Hypoalbuminemic edema, retroauricular swelling and severe eosinophilia: What is the missing link?

21 February 2016
Author(s): Silvia Giorgetti, Mario Comassi

A 32-year-old Pakistani man without significant comorbidity presented to the Emergency Department with generalized edema. Physical examination highlighted lower limbs and scrotum swelling with tense-... more

Terra firma-forme dermatosis

24 February 2016
Author(s): Mariacarmela Santarpia, Claudio Guarneri

A 75-year-old woman who was positive for metastatic breast cancer and left radical mastectomy complained of two month-history of dirty-appearing skin, composed of subtle but clear-cut brown to... more

Letter to the Editor

First data from Latvian chronic thromboembolic pulmonary hypertension registry

4 February 2016
Author(s): Andris Skride, Kristaps Sablinskis, Ainars Rudzitis, Krista Lesina, Aivars Lejnieks

Pulmonary hypertension (PH) is a complex, progressing and debilitating disease associated with poor prognosis. Chronic thromboembolic pulmonary hypertension (CTEPH) — a distinct subtype of PH is the... more

Primary upper extremity deep vein thrombosis: Clinical characteristics and outcome according to the presence of thoracic outlet syndrome

12 February 2016
Author(s): A. Riera-Mestre, A. Buonaro, A. Romera Villegas, X. Corbella

Venous thromboembolism (VTE) affects approximately 100 people per 100,000 population per year. Approximately one-third present as pulmonary embolism (PE) and two-thirds as deep vein thrombosis (DVT... more

Reply letter to the comments

17 February 2016
Author(s): Chia-Hung Kao

We very appreciate these comments [1]. All of our manuscripts have been carefully and critically reviewed many times by these professional editors and experienced reviewers independently provided by... more

Kounis syndrome: Aspects on pathophysiology and management

18 February 2016
Author(s): George D. Soufras, Dimitrios Lianas, Nicholas Patsouras, Grigorios Tsigkas, Nicholas G. Kounis

We read with the great interest the excellent and concise review of Filippo Fassio et al. [1] focused on Kounis syndrome and its treatment. Since the description of this syndrome has paved the... more

Kounis syndrome: Aspects on pathophysiology and management

25 February 2016
Author(s): Enrico Heffler, Filippo Fassio

We thank Kounis and coll. for their Letter to the Editor [1] commenting and congratulating for our recently published article “Kounis syndrome: A concise review with focus on management” [2].

Letters to the Editor

Early market access for unauthorized drugs in Italy: The value-based price for reimbursement decisions

3 February 2016
Author(s): Dario Maratea, Francesca Venturini

A major challenge for regulatory agencies is balancing the need for rapid access to drugs for new indications against the limited information on their benefit–risk ratio. The processes described by... more

Letter to the editor: Mean platelet volume and cardiovascular risk factors

4 February 2016
Author(s): Cengiz Beyan, Esin Beyan

We read with a great interest the article of Sansanayudh et al. about mean platelet volume (MPV) and cardiovascular risk factors [1]. They found that the higher MPV associated with some... more

Original Article

Increased risk of concurrent gastroesophageal reflux disease among patients with Sjögren's syndrome: A nationwide population-based study

4 February 2016
Author(s): Chen-Shu Chang, Chun-Hui Liao, Chih-Hsin Muo, Chia-Huang Kao

Little data is available on the risk of gastroesophageal reflux disease in patients diagnosed with Sjögren's syndrome.

The effect of metformin on prolactin levels in patients with drug-induced hyperprolactinemia

5 February 2016
Author(s): Robert Krysiak, Karolina Kowalcze, Witold Szkrobka, Boguslaw Okopien

In bromocriptine-treated hyperprolactinemic patients with impaired glucose tolerance, metformin was found to reduce plasma levels of prolactin. No previous study has investigated its impact on plasma... more

Heterogeneity of the prognostic significance of B-type natriuretic peptide levels on admission in patients hospitalized for acute heart failure syndromes

12 February 2016
Author(s): Yuichiro Minami, Katsuya Kajimoto, Naoki Sato, Nobuhisa Hagiwara, Teruo Takano, Alexandre Mebazaa, The ATTEND Study Investigators

We hypothesized that variation in baseline characteristics of patients with acute heart failure syndromes (AHFS) affects the prognostic significance of B-type natriuretic peptide (BNP) levels because... more

A Body Shape Index and Body Roundness Index: Two new body indices for detecting association between obesity and hyperuricemia in rural area of China

16 February 2016
Author(s): Naijin Zhang, Ye Chang, Xiaofan Guo, Yintao Chen, Ning Ye, Yingxian Sun

The first objective was to examine whether A Body Shape Index (ABSI) and Body Roundness Index (BRI) can identify hyperuricemia in rural China. The second aim was to compare the relative strength of... more

Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis?

20 February 2016
Author(s): I. Mikolasevic, S. Milic, D. Stimac, L. Zaputovic, V. Lukenda Zanko, T. Gulin, I. Jakopcic, D. Klaric, M. Gulin, L. Orlic

We investigated the association among long-term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPI use... more

Association between bullous pemphigoid and hypovitaminosis D in older inpatients: Results from a case–control study

22 February 2016
Author(s): M.E. Sarre, C. Annweiler, E. Legrand, L. Martin, O. Beauchet

To compare serum vitamin D status in older inpatients with bullous pemphigoid (BP) and matched inpatients without BP, and to examine whether hypovitaminosis D, a high comorbidity burden or their... more

Association of statin use and the risk of end-stage renal disease: A nationwide Asian population-based case–control study

24 February 2016
Author(s): Shih-Yi Lin, Cheng-Li Lin, Wu-Huei Hsu, Cheng-Chieh Lin, Chiz-Tzung Chang, Chia-Hung Kao

Although experimental models have shown that statins could alleviate glomerular damage and decrease urinary protein excretion, the renal effects of statins remain unclear. A case–control study was... more

Appropriateness of PPI prescription in patients admitted to hospital: Attitudes of general practitioners and hospital physicians in Italy

26 February 2016
Author(s): Francesca Lodato, Elisabetta Poluzzi, Emanuel Raschi, Carlo Piccinni, Ariola Koci, Valentina Olivelli, Chiara Napoli, Giulia Corvalli, Elena Nalon, Fabrizio De Ponti, Marco Zoli

Proton pump inhibitor (PPI) prescriptions have raised concern for both huge increase of health expenditure and possible long-term adverse effects.

Differential associations between glomerular filtration rate and duration of obesity depending on the presence or absence of left ventricular diastolic dysfunction

27 February 2016
Author(s): Juan Ybarra, Joan Sánchez-Hernández, Ramon Vilallonga, June H. Romeo

A robust and consistent association between increasing body mass index (BMI) and chronic kidney disease (CKD) has been reported in several observational studies. Obesity remains the main preventable... more

Circadian variation of cardiogenic pulmonary oedema

28 February 2016
Author(s): Jitka Callerova, Roman Skulec, Karel Kucera, Jiri Knor, Patrik Merhaut, Vladimir Cerny

Circadian variation of in-hospital acute cardiogenic pulmonary oedema (CPE) with the highest occurrence in the early morning has been reported repeatedly. However, no study evaluating circadian... more