Whereas ongoing oral anticoagulation (OAC), with either warfarin or a non-vitamin K-antagonist oral anticoagulant (NOAC), should generally be confirmed in patients with atrial fibrillation (AF) who undergo percutaneous coronary intervention with stent (PCI-S) [1–2], the type (i.e., warfarin versus NOAC) and dose (i.e., standard versus reduced) of the oral anticoagulant to be added to dual anti platelet therapy of aspirin and clopidogrel (DAPT) when AF develops early after PCI-S need necessarily to be chosen.