Cryofibrinogen is a cryoprotein that forms only in plasma and not in serum. In patients screened for a cryopathy, prevalence of cryofibrinogenemia varies from 12% to 51% [1–3]. Most studies concerning essential and secondary cryofibrinogenemia excluded patients with concomitant cryoglobulinemia . In cryoglobulinemic patients, the presence of cryofibrinogenemia has been shown to be associated with cryoglobulinemia vasculitis [4,5]. Moreover, we found that patients with both cryoproteins had more frequently a cancer than patients with isolated cryoglobulinemia .