Glomerular filtration rate is associated with free triiodothyronine in euthyroid subjects: Comparison between various equations to estimate renal function and creatinine clearance

Published: 24 October 2017
Author(s): Josephine L.C. Anderson, Eke G. Gruppen, Lynnda van Tienhoven-Wind, Michele F. Eisenga, Hanne de Vries, Ron T. Gansevoort, Stephan J.L. Bakker, Robin P.F. Dullaart
Issue: October 2017
Section: Original Article

Effects of variations in thyroid function within the euthyroid range on renal function are unclear. Cystatin C-based equations to estimate glomerular filtration rate (GFR) are currently advocated for mortality and renal risk prediction. However, the applicability of cystatin C-based equations is discouraged in patients with overt thyroid dysfunction, since serum cystatin C and creatinine levels are oppositely affected by thyroid dysfunction. Here, we compared relationships of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) with various measures of kidney function in euthyroid subjects.