Serum cartilage oligomeric matrix protein levels as a novel non-invasive biomarker for liver fibrosis in patients with chronic viral hepatitis? It is too early

Published: 18 April 2017
Author(s): Rui Huang, Juan Xia, Xiaomin Yan, Yong Liu, Chao Wu
Issue: April 2017
Section: Letter to the Editor

We read with great interest the recently published article by Zachou et al., in which they investigated the possible application of serum cartilage oligomeric matrix protein (COMP) levels as a novel non-invasive marker of fibrosis in patients with chronic viral hepatitis (CVH) and compared this marker with histology, transient elastography (TE), APRI and FIB-4 for the estimation of fibrosis stage [1]. They concluded that serum COMP levels performed as well as TE, APRI and FIB-4 score in detecting cirrhosis in CVH patients [1].