Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients

Published: 2 August 2019
Author(s): Deborah Rudin, Julia Spoendlin, Anca L. Cismaru, Evangelia Liakoni, Nicolas Bonadies, Ursula Amstutz, Christoph R. Meier, Stephan Krähenbühl, Manuel Haschke
Issue: August 2019
Section: Original Article

Reports of metamizole-induced neutropenia have increased in Switzerland and Germany over the last decades, most likely reflecting increased use of metamizole. To date, there are no effective strategies to identify patients at increased risk of metamizole-induced neutropenia. In this observational, multi-center comparative study, characteristics of patients with metamizole-associated neutropenia were compared with patients treated with metamizole without developing adverse hematological reactions.