European Journal of Internal Medicine

August 2019

33 Articles

No Section

D-dimer levels enhance the discriminatory capacity of bleeding risk scores for predicting in-hospital bleeding events in acute pulmonary embolism

16 August 2019
Author(s): Marta Skowrońska, Aleksandra Furdyna, Michał Ciurzyński, Szymon Pacho, Piotr Bienias, Piotr Palczewski, Katarzyna Kurnicka, Krzysztof Jankowski, Anna Lipińska, Karolina Uchacz, Bartosz Karolak, Piotr Pruszczyk

Bleeding is a major complication of anticoagulation in acute pulmonary embolism (APE) while estimating individual bleeding risk remains challenging. Elevated D-dimer levels (DD) have been shown to... more

Letter to the Editor

Lung ultrasonography in pulmonary tuberculosis: Integrating chest radiology? Authors' reply

28 August 2019
Author(s): Michele Montuori, Chiara Cogliati

We would like to thank Mirijello, De Cosmo and Sperandeo for their interest in our work [1]. In our article we evaluated lung ultrasonography (LUS) signs and their accuracy in the diagnosis of... more

Angiotensin receptor blockers therapy and cancer risk

1 August 2019
Author(s): Shih-Wei Lai

Angiotensin receptor blockers are widely prescribed to treat hypertension. The relationship between angiotensin receptor blockers and cancer is extensively studied. Recently one meta-analysis... more

The potential role of SLE-key test in identifying patients with Systemic Lupus Erythematosus: Results from a prospective, real-world experience

2 August 2019
Author(s): Massimo Radin, Savino Sciascia, Irene Cecchi, Giulio Mengozzi, Dario Roccatello

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by extremely heterogeneous clinical manifestations [1].

Listeria infection in patients using anti-TNFα treatment: Should there be preventive strategies?

5 August 2019
Author(s): Bouwe P. Krijthe, Maud A.W. Hermans, Carolina A.M. Schurink, Paul L.A. van Daele

Recently, one of our patients was admitted to the Intensive Care Unit with a severe listeria sepsis while using adalimumab, an anti- TNFα biological. It is a 50-year old man of Moroccan descent with... more

Additional predictive value of C-reactive protein to GRACE score in patients with acute coronary syndrome

6 August 2019
Author(s): Simone Persampieri, Diego Castini, Federica Valli, Ludovico Sabatelli, Stefano Carugo

The awareness that active inflammation plays a major role in the initiation and progression of atherosclerosis dates back to the seminal observations of Ross et al. [1]. Although this concept relies... more

What is the value of repeated upper gastro intestinal endoscopy in cases of a previous endoscopy without macroscopic abnormalities?

6 August 2019
Author(s): R.J.L.F. Loffeld, B. Liberov, P.E.P. Dekkers

Upper gastrointestinal endoscopy (UGE) is routinely used in daily practice [1,2]. Some patients are repeatedly sent for UGE despite the fact that a previous procedure showed no abnormalities.... more

Ultrasound and hepatic abscess: A successful alliance for the internist

6 August 2019
Author(s): A. Boccatonda, D. D'Ardes, G. Cocco, F. Cipollone, C. Schiavone

even if liver abscess is a rare disease, with an incidence ranging from about 8 to 20 cases/100000 hospital admissions, it is related to high mortality rates. Mortality ranges between 8% and 31% [1,2... more

Prevalence of use and appropriateness of antidepressants prescription in acutely hospitalized elderly patients

9 August 2019
Author(s): Franchi Carlotta, Rossio Raffaella, Ardoino Ilaria, Nobili Alessandro, Mannucci Pier Mannuccio, REPOSI Collaborators

Depression is often under-recognized in older patients, even if antidepressants (AD) are commonly prescribed, with a prevalence of use that increase with ageing [1]. Nevertheless, even if a diagnosis... more

Clinical course and management of adult-onset immune-mediated cytopenia associated with Kabuki syndrome

16 August 2019
Author(s): Silvia Cantoni, Bruno Fattizzo

Kabuki syndrome (KS) is a rare genetic disease characterized by congenital malformations, growth deficiency, mental retardation and altered immune regulation [1]. Autoimmune cytopenias may develop... more

Predictors of mortality of bloodstream infections among internal medicine patients: Mind the complexity of the septic population! Authors' reply

22 August 2019
Author(s): Matthaios Papadimitriou-Olivgeris, Hervé Duplain

We would like to thank Dr. Tosoni and his colleagues for commenting on our recent article and we appreciate this opportunity to further clarify our work [1]. We fully agree that Internal Medicine... more

Clinical course of primary immune thrombocytopenia with positive antiphospholipid antibodies

22 August 2019
Author(s): Ana Clara Ladeira Cruz, Marina Pereira Colella, Erich Vinícius De Paula, Joyce Annichinno-Bizzachi, Fernanda Andrade Orsi

Antiphospholipid antibodies (aPL) are frequently detected in immune thrombocytopenia (ITP) and whether they play a role in ITP prognosis is controversial. Previous studies have shown that aPL... more

Is morphine safe in acute decompensated heart failure? A systematic review of the literature

22 August 2019
Author(s): Daniele Orso, Genny Boaro, Emanuela Cassan, Nicola Guglielmo

Acute decompensated heart failure (ADHF) is one of the most common diseases in the emergency department worldwide. Historically one of the most recommended therapeutic drugs, in addition to diuretics... more

Estimation of the attitude toward diet in hospitalized patients with diabetes by assessing bedside snacks - A common practice based on false assumptions

23 August 2019
Author(s): Lihi Rozner, Yuval Mizrakli, Victor Novack, Idit F. Liberty, Gal Ifergane

Moral judgment and Stigmatization are common in our society [1], and health care professionals are no different [2–5]. Patients who trigger moral judgment are often patients in which the medical... more

Pegloticase and lowering blood pressure in refractory gout; is it uric acid or hydrogen peroxide?

27 August 2019
Author(s): Mehdi A. Fini, Kurt R. Stenmark

Epidemiologic and experimental studies have demonstrated that high levels of serum uric acid ((SUA) Hyperuricemia) are strongly associated with poorly controlled hypertension, arterial stiffness,... more

Original Article

Methotrexate therapy is not associated with increased liver stiffness and significant liver fibrosis in rheumatoid arthritis patients: A cross-sectional controlled study with real-time two-dimensional shear wave elastography

29 August 2019
Author(s): Gian Luca Erre, Maria Luisa Cadoni, Pierluigi Meloni, Floriana Castagna, Arduino Aleksander Mangoni, Matteo Piga, Giuseppe Passiu, Ciriaco Carru, Angelo Zinellu, Gianpaolo Vidili

To explore the significance of the association between treatment with methotrexate (MTX) and liver stiffness in rheumatoid arthritis (RA) patients.

Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients

2 August 2019
Author(s): Deborah Rudin, Julia Spoendlin, Anca L. Cismaru, Evangelia Liakoni, Nicolas Bonadies, Ursula Amstutz, Christoph R. Meier, Stephan Krähenbühl, Manuel Haschke

Reports of metamizole-induced neutropenia have increased in Switzerland and Germany over the last decades, most likely reflecting increased use of metamizole. To date, there are no effective... more

Functional benefit of smoking cessation in severe COPD patients undergoing bronchial valve implantation

3 August 2019
Author(s): Aldo Pezzuto, Michela D'Ascanio, Alessio Grieco, Alberto Ricci

Tobacco smoke is the leading cause of chronic obstructive pulmonary disease. The aim of this study is to highlight the effectiveness of smoking cessation along with bronchial valve implantation in... more

The international St-aging system as a prognostic marker in general senior population: Findings from the EPIDOS cohort study

3 August 2019
Author(s): Marie Pouzoullic, Anne-Marie Schott, Dolores Sánchez-Rodríguez, Regis Bataille, Cedric Annweiler, On behalf of the SOCOS group

The International Staging System (ISS) -calculated from serum albumin and beta-2 microglobulin (β2m)- is an established prognostic marker in multiple myeloma (MM), which has also been suggested to... more

Determination of salivary cortisol to assess time-related changes of the adrenal response to stress in critically ill patients

6 August 2019
Author(s): Soraya Puglisi, Andrea Pizzuto, Barbara Laface, Francesco Panero, Franco Aprà, Enrico Palmas, Paola Perotti, Giuseppe Reimondo, Adriana Boccuzzi, Massimo Terzolo

The value of salivary cortisol measurement to study stress-related adrenal response is controversial. The study aim was to assess the role of salivary cortisol measurement to detect time-related... more

No major reduction in bone mineral density after long-term treatment of patients with Celiac Disease

8 August 2019
Author(s): Petter Hære, Ole Høie, Knut E.A. Lundin, Glenn Haugeberg

Celiac Disease (CD) is a disorder characterized by mucosal inflammation and villous atrophy (VA) in the small intestine. The disease has been shown to affect at least 1% of the European population [1... more

Pancreatic exocrine insufficiency in diabetes mellitus - prevalence and characteristics

8 August 2019
Author(s): Eirik Søfteland, Jakob Lykke Poulsen, Jakob Starup-Linde, Trine Tang Christensen, Søren Schou Olesen, Simran Singh, Peter Vestergaard, Asbjørn Mohr Drewes, Georg Dimcevski

The prevalence of pancreatic exocrine insufficiency (PEI) in diabetes mellitus (DM) varies widely between studies, which may be explained by methodological problems. We aimed to establish the... more

Serum 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage, is associated with mortality independent of inflammation in chronic kidney disease

9 August 2019
Author(s): Lu Dai, Makoto Watanabe, Abdul Rashid Qureshi, Hideyuki Mukai, Anna Machowska, Olof Heimbürger, Peter Barany, Bengt Lindholm, Peter Stenvinkel

Oxidative stress and low-grade systemic inflammation are common interrelated sequelae of chronic kidney disease (CKD) that associate with mortality. We investigated the association of serum 8-hydroxy... more

Tramadol- and codeine-induced severe hyponatremia: A Swedish population-based case-control study

12 August 2019
Author(s): Henrik Falhammar, Jan Calissendorff, Jakob Skov, David Nathanson, Jonatan D. Lindh, Buster Mannheimer

Although tramadol and codeine occasionally have been reported to cause hyponatremia the evidence is scarce. The objective of this investigation was to study the association between weak opioids (... more

Transcutaneous carbon dioxide monitoring as a predictive tool for all-cause 6-month mortality after acute pulmonary embolism

12 August 2019
Author(s): Ourania S. Kotsiou, Vasileios Karadontas, Zoe Daniil, Epameinondas Zakynthinos, Konstantinos I. Gourgoulianis

Pulmonary embolism (PE) frequently remains undiagnosed. The partial pressure of carbon dioxide (PaCO2), a surrogate of dead-space ventilation, is useful in the evaluation of the degree of pulmonary... more

Pulmonary hypertension in patients with myeloproliferative neoplasms: A large cohort of 183 patients

14 August 2019
Author(s): Geoffroy Venton, Mihai Turcanu, Julien Colle, Franck Thuny, Safia Chebrek, Laure Farnault, Cédric Mercier, Vadim Ivanov, Raphaëlle Fanciullino, Pierre Suchon, Pierre-André Jarrot, Karim Aissi, Pauline Roche, Jennifer Cautela, Robin Arcani, Regis Costello

Chronic myeloproliferative neoplasms (MPN) are recognized as a cause of pulmonary hypertension (pH). We ought to describe the prevalence and characteristics of PH in a cohort of MPN who were screened... more

Statin and all-cause mortality in patients receiving anticoagulant therapy for venous thromboembolism. Data from the RIETE registry

16 August 2019
Author(s): Carmine Siniscalchi, Roberto Quintavalla, Anna Rocci, Antoni Riera-Mestre, Javier Trujillo-Santos, José María Suriñach, Luis Jara-Palomares, Behnood Bikdeli, Farès Moustafa, Manuel Monreal, the RIETE Investigators

The clinical outcomes during the course of anticoagulation in patients with venous thromboembolism (VTE) using statins remain controversial.

3P association (3PAs): Pituitary adenoma and pheochromocytoma/paraganglioma. A heterogeneous clinical syndrome associated with different gene mutations

17 August 2019
Author(s): Fernando Guerrero-Pérez, Carmen Fajardo, Elena Torres Vela, Olga Giménez-Palop, Arturo Lisbona Gil, Tomas Martín, Natividad González, Juan José Díez, Pedro Iglesias, Mercedes Robledo, Carles Villabona

Pituitary adenomas (PA) associated with pheochromocytomas/paragangliomas (Pheo/PGL), also known as “the three P association” or “3PAs” could be the results of coincidence, but new evidence supports a... more

Assessment of frequency and reporting of design changes among clinical drug trials published in influential medical journals

19 August 2019
Author(s): Daniel Shepshelovich, Dafna Yahav, Ariadna Tibau, Eitan Amir

Modifications of primary outcome measures after trial initiation can undermine their scientific validity. We aimed to quantify these changes and to characterize potential predictors in clinical drug... more

Vaccination against influenza and pneumococcal infections in patients with autoimmune disorders under biological therapy: Coverage and attitudes in patients and physicians

21 August 2019
Author(s): Hajer Lejri-El Euchi, Emmanuel Chirpaz, Aurélie Foucher, Nathalie Sultan-Bichat, Andry Randrianjohany, Patrice Poubeau, Etienne Gamon, Céline Roussin, Sophie Osdoit, Loïc Raffray

Patients under biological therapy for auto-immune disease are considered immunosuppressed and several recent recommendations highlight the need for vaccination against influenza and pneumococcal... more

The efficacy and safety of bortezomib-based chemotherapy for immunoglobulin light chain amyloidosis: A systematic review and meta-analysis

22 August 2019
Author(s): Baojian Liu, Ming Bai, Yan Wang, Di Wang, Jin Zhao, Lu Li, Ruijuan Dong, Shiren Sun

The role of bortezomib in the treatment of immunoglobulin light chain (AL) amyloidosis is not well defined. We performed this meta-analysis to evaluate the efficacy and safety of bortezomib-based... more

Influence of the length of hospitalisation in post-discharge outcomes in patients with acute heart failure: Results of the LOHRCA study

23 August 2019
Author(s): Òscar Miró, Joan Padrosa, Koji Takagi, Étienne Gayat, Víctor Gil, Pere Llorens, Francisco Javier Martín-Sánchez, Pablo Herrero-Puente, Javier Jacob, María Mir Montero, Josep Tost, María Pilar López Díez, Lissete Traveria, Raquel Torres-Gárate, María Isabel Alonso, Carmen Agüera, Amparo Valero, Patricia Javaloyes, W. Frank Peacock, Héctor Bueno, Alexandre Mebazaa, on behalf of the ICA-SEMES Research Group, Marta Fuentes, Cristina Gil, Héctor Alonso, Pablo Garmila, Guillermo Llopis García, María Cecilia Yáñez-Palma, Sergio Iglesias López, Rosa Escoda, Carolina Xipell, Carolina Sánchez, Josep María Gaytan, María José Pérez-Durá, Eva Salvo, José Pavón, Antonio Noval, José Manuel Torres, María Luisa López-Grima, Amparo Valero, Marian Ángeles Juan, Alfons Aguirre, Julián Errasti Morales, Silvia Mínguez Masó, María Isabel Alonso, Francisco Ruiz, José Miguel Franco, Ana Belén Mecina, Josep Tost, Susana Sánchez, Virginia Carbajosa, Pascual Piñera, José Andrés Sánchez Nicolás, Raquel Torres Garate, Aitor Alquezar, Miguel Alberto Rizzi, Sergio Herrera, Alex Roset, Irene Cabello, Fernando Richard, José María Álvarez Pérez, María Pilar López Diez, Joaquín Vázquez Álvarez, Belén Prieto García, María García García yMarta Sánchez González, Patricia Javaloyes, Víctor Marquina, Inmaculada Jiménez, Néstor Hernández, Benjamín Brouzet, Sergio Ramos, Ana López, Juan Antonio Andueza, Rodolfo Romero, Martín Ruíz, Roberto Calvache, María Teresa Lorca, Luis Calderón, Beatriz Amores Arriaga, Beatriz Sierra, Enrique Martín Mojarro, Lisette Travería Bécquer, Guillermo Burillo, Lluís Llauger García, Gerard Corominas LaSalle, Carmen Agüera Urbano, Ana Belén García Soto, Elisa Delgado Padial, Ester Soy Ferrer, Manuel Garrido, Francisco Javier Lucas, Rut Gaya, Carlos Bibiano, María Mir, Beatriz Rodríguez, Natalia Sánchez, José Luis Carballo, Esther Rodríguez-Adrada, Belén Rodríguez

To investigate the relationship between length of hospitalisation (LOH) and post-discharge outcomes in acute heart failure (AHF) patients and to ascertain whether there are different patterns... more

Diagnostic model of visceral leishmaniasis based on bone marrow findings. Study of patients with clinical suspicion in which the parasite is not observed

26 August 2019
Author(s): Alfredo Bermejo Rodriguez, Jose Manuel Ruiz Giardin, Jesus Garcia Martinez, Juan Victor San Martin Lopez, Adela Castaneda de la Mata, Daniel Lopez Lacomba, Jeronimo Jaqueti Aroca, Stefan Walter

Visceral Leishmaniasis (VL) is a serious protozoal disease endemic in diverse areas, including the southern area of Madrid (Spain), where an outbreak was detected in 2009. The objective of this work... more