Pegloticase and lowering blood pressure in refractory gout; is it uric acid or hydrogen peroxide?

Published: 27 August 2019
Author(s): Mehdi A. Fini, Kurt R. Stenmark
Issue: August 2019
Section: Letter to the Editor

Epidemiologic and experimental studies have demonstrated that high levels of serum uric acid ((SUA) Hyperuricemia) are strongly associated with poorly controlled hypertension, arterial stiffness, metabolic syndrome, chronic kidney disease and cardiovascular disease [1–3]. Likewise, high SUA in patients with gout was predictive of and associated with hypertension, atherosclerosis, high urinary albumin levels and systemic vascular injury [4]. Despite these associations, the causal role of uric acid (UA) in cardiovascular diseases has been the center of debate in part due to some inconclusive data from human treatment studies of hyperuricemia with XOR inhibitors.