Is morphine safe in acute decompensated heart failure? A systematic review of the literature

Published: 22 August 2019
Author(s): Daniele Orso, Genny Boaro, Emanuela Cassan, Nicola Guglielmo
Issue: August 2019
Section: Letter to the Editor

Acute decompensated heart failure (ADHF) is one of the most common diseases in the emergency department worldwide. Historically one of the most recommended therapeutic drugs, in addition to diuretics and nitrates, is morphine. Despite some handbooks and guidelines still accept its use [1,2], morphine has never demonstrated a benefit on mortality of patients treated for ADHF. Furthermore, recent studies have highlighted some potential deleterious effects of morphine [3].