Determinants of thromboxane biosynthesis in patients with moderate to severe chronic kidney disease

Published: 4 July 2016
Author(s): Natale Vazzana, Francesca Santilli, Stefano Lattanzio, Mario Liani, Luciano Giacci, Goffredo Del Rosso, Filippo Salvati, Andrea Boccatonda, Patrizia Ferroni, Giovanni Davì
Issue: July 2016
Section: Original Article

Mechanisms of accelerated atherothrombosis in patients with chronic kidney disease (CKD) are only partly characterized. The aims of this study were to evaluate the extent of thromboxane (TX)-dependent platelet activation in patients with CKD, and to characterize the determinants of altered TX biosynthesis in this setting, with particular reference to enhanced lipid peroxidation, low grade inflammation and CKD-related anemia.