European Journal of Internal Medicine

July 2016

30 Articles

Internal Medicine Flashcard

Syncope with transient diffuse T-wave inversions

29 July 2016
Author(s): Talal Alnabelsi, Vincent Figueredo

A 64year old African-American male with a history of hypertension and tobacco abuse presented after collapsing at home. The patient was watching television but then lost consciousness and was woken... more

Letter to the Editor

Ulcerative colitis: A scientometric approach to the global research output and network

1 July 2016
Author(s): Norman Schöffel, Michael H.K. Bendels, David A. Groneberg

Ulcerative colitis (UC) is the most common type of inflammatory bowel disease worldwide [1]. Despite decades of scientific work there are many aspects of uncertainty leading to an ongoing interest in... more

Obesity or smoking: Which factor contributes more to the incidence of myocardial infarction? Authors' Reply

4 July 2016
Author(s): Dror Dicker, Becca S. Feldman, Arriel Benis, Moshe Hoshen

The authors thank Shiri for his questions and concerns [1] and appreciate the opportunity to respond to them. The primary concern was that the study population may be sicker than the general Israeli... more

The secret of the questions: medical interview in 21st century

7 July 2016
Author(s): Marco Zuin, Gianluca Rigatelli, Giovanni Zuliani, Giuseppe Faggian, Loris Roncon

Despite the progress in diagnosis and disease management achieved over the last 20years, the role of anamnesis in routine clinical practice has drastically changed [1]. In fact, both the... more

Ethical limits to biomedical publications?

11 July 2016
Author(s): P. Charlier, S. Deo, M.F. Mamzer-Bruneel, C. Hervé

Out of the political implications of the recent editorial signed by editors (not scholars!) in the Lancet about the Israelo-Palestinian conflict, one may ask if some ethical limits exist to... more

“The sins of the fathers will be visited upon the children”: Congenital syphilis and leg braces pictorial depiction in eighteenth century Britain

12 July 2016
Author(s): R. Bianucci, A. Perciaccante

Treponema pallidum pallidum, the agent of venereal syphilis, is transmitted by sexual contact and can be spread across the placental barrier. The congenital form can occur at any stage of maternal... more

Homocysteine in nonalcoholic steatohepatitis: A reply

13 July 2016
Author(s): Stergios A. Polyzos, Jannis Kountouras

We read with interest the letter-to-the-Editor of Leach et al. [1], commenting on our [2–4] and their [5] previous works and considerations. We hereby highlight some considerations raised by Leach et... more

Experience pays off! Endocrine centres are essential in the care of patients with adrenal insufficiency

18 July 2016
Author(s): Daniela Kampmeyer, Hendrik Lehnert, Heiner Moenig, Christian S. Haas, Birgit Harbeck

Patients with adrenal insufficiency (AI) require continuous glucocorticoid (GC) replacement treatment to restore well-being and to prevent life-threatening complications. Knowledge of symptoms of... more

Broadband access, housing and car ownership as deprivation predictors of the emergency medical admission

19 July 2016
Author(s): Richard Conway, Sean Cournane, Declan Byrne, Deirdre O'Riordan, Seamus Coveney, Bernard Silke

The rate at which emergency medical conditions present is dependent on social deprivation; an eightfold difference in the annual incidence rate from 5/1000 to 40/1000 may occur [1]. The explanation... more

Are we really tackling the "evidence-based medicine issue" in Alzheimer's disease?

23 July 2016
Author(s): Marco Canevelli, Giuseppe Bruno, Nicola Vanacore, Carlo de Lena, Matteo Cesari

Age-related medical conditions are increasingly becoming a research priority given the relevant burden for healthcare systems and the projected demographic changes occurring in our societies.... more

Letters to the Editor

Falling in the elderly; a clarification of results

8 July 2016
Author(s): B.A. Mateen, F.J. Király

Upon reading the article “Falling in the elderly: Do statistical models matter for performance criteria of fall prediction? Results from two large population-based studies”, which was recently... more

Risk of osteonecrosis in patients with systemic lupus erythematosus: A nationwide population-based study

14 July 2016
Author(s): A. Dima, A.B. Pedersen, L. Pedersen, C. Baicus, R.W. Thomsen

The occurrence of osteonecrosis (ON) in patients with systemic lupus erythematosus (SLE) was first quantified by Dubois et al. [1] in 1960, in their report describing ON in 11 out of 400 SLE patients... more

Addressing exploitation of poor clinical trial participants in North America and the European Union

14 July 2016
Author(s): Rafael Dal-Ré, Annette Rid, Ezekiel Emanuel, David Wendler

One of the cornerstones of ethical research is to protect participants from exploitation [1]. Exploitation occurs when investigators, sponsors or others take unfair advantage of participants by... more

Parenteral routes for opioid administration in cancer pain management

19 July 2016
Author(s): Sebastiano Mercadante

Oral opioid administration is preferable in most cancer patients with pain. However, while the oral route is not available for different reasons, an alternative route of administration is often... more

Obesity is a risk factor for asthma in women but not in men among elder people in China

20 July 2016
Author(s): Jiahui Qian, Xiaohui Ren

Obesity and asthma are important health issues and a positive association between them has been reported [1–3]. However, the reports were mainly based on school-age children and there are few reports... more

A survey among hospital specialists and pharmacists about biosimilars

23 July 2016
Author(s): Luca Pasina, Gianluigi Casadei, Alessandro Nobili

Biological medicines are essential for many acute and chronic conditions [1]. A biosimilar is a version similar to an authorized original biological product with clinical comparability that must be... more

Narrative Review

Aging of the endocrine system and its potential impact on sarcopenia

30 July 2016
Author(s): Giovanni Vitale, Matteo Cesari, Daniela Mari

Sarcopenia, occurring as a primary consequence of aging, is a progressive generalized decline of skeletal muscle mass, strength and function. The pathophysiology of sarcopenia is complex and... more

Original Article

Three year functional changes and long-term mortality hazard in community-dwelling older men

3 July 2016
Author(s): Stefanie De Buyser, Mirko Petrovic, Youri Taes, Kaatje Toye, Jean-Marc Kaufman, Stefan Goemaere, Bruno Lapauw

Low levels of physical function have been associated with higher mortality hazard in older persons. However, few studies have investigated the association between functional changes and subsequent... more

Determinants of thromboxane biosynthesis in patients with moderate to severe chronic kidney disease

4 July 2016
Author(s): Natale Vazzana, Francesca Santilli, Stefano Lattanzio, Mario Liani, Luciano Giacci, Goffredo Del Rosso, Filippo Salvati, Andrea Boccatonda, Patrizia Ferroni, Giovanni Davì

Mechanisms of accelerated atherothrombosis in patients with chronic kidney disease (CKD) are only partly characterized. The aims of this study were to evaluate the extent of thromboxane (TX)-... more

Vitamin K and non-vitamin K antagonists oral anticoagulants for non-valvular atrial fibrillation in real-life

6 July 2016
Author(s): Michela Giustozzi, Maria Cristina Vedovati, Paolo Verdecchia, Lucia Pierpaoli, Melina Verso, Serenella Conti, Federica Cianella, Emanuela Marchesini, Esmeralda Filippucci, Giancarlo Agnelli, Cecilia Becattini

Current guidelines recommend vitamin K antagonists (VKAs) or non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in patients with non-valvular atrial fibrillation (AF).

Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival

7 July 2016
Author(s): Mehmet Kanbay, Baris Afsar, Dimitrie Siriopol, Hilmi Umut Unal, Murat Karaman, Mutlu Saglam, Mustafa Gezer, Ahmet Taş, Tayfun Eyileten, Ahmet Kerem Guler, İbrahim Aydin, Yusuf Oguz, Kayhan Tarim, Adrian Covic, Mahmut Ilker Yilmaz

Endostatin, generated from collagen XVIII, and endorepellin, possess dual activity as modifiers of both angiogenesis and endothelial cell autophagy. Plasma endostatin levels are elevated in a large... more

A new definition of health? An open letter of autochthonous peoples and medical anthropologists to the WHO

7 July 2016
Author(s): P. Charlier, Y. Coppens, J. Malaurie, L. Brun, M. Kepanga, V. Hoang-Opermann, J.A. Correa Calfin, G. Nuku, M. Ushiga, X.E. Schor, S. Deo, J. Hassin, C. Hervé

Currently, for many practitioners (hospital and liberals) and researchers (including public health), the WHO definition of health is outdated: first it seems more utopian than pragmatic; then, it... more

Severity of coronary artery disease is an independent risk factor for decline in kidney function

9 July 2016
Author(s): Osman Turak, Baris Afsar, Dimitrie Siriopol, Cagri Yayla, Fatih Oksuz, Kumral Cagli, Alexandru Burlacu, Adrian Covic, Mehmet Kanbay

Chronic kidney disease (CKD) and cardiovascular disease are closely interrelated and the presence of one condition synergistically affects the prognosis of the other, in a negative manner. There are... more

Diagnostic performances of M-protein tests according to the clinical presentations of kidney disease

12 July 2016
Author(s): Eun Hee Koo, Jung-ho Shin, Hye Ryoun Jang, Hyung-Doo Park, Gee-Young Kwon, Wooseong Huh, Dae Joong Kim, Yoon-Goo Kim, Ha Young Oh, Jung Eun Lee

Screening for monoclonal immunoglobulin (MIg) is critical in patients with kidney disease.

Randomized comparison between the invasive and conservative strategies in comorbid elderly patients with non-ST elevation myocardial infarction

13 July 2016
Author(s): Juan Sanchis, Eduardo Núñez, José Antonio Barrabés, Francisco Marín, Luciano Consuegra-Sánchez, Silvia Ventura, Ernesto Valero, Mercè Roqué, Antoni Bayés-Genís, Bruno García del Blanco, Irene Dégano, Julio Núñez

Comorbid elderly patients with non-ST-elevation myocardial infarction (non-STEMI) are underrepresented in randomized trials and undergo fewer cardiac catheterizations according to registries. Our aim... more

Pre-hospital alarm activation for STEMI patients undergoing primary percutaneous coronary intervention in the era of transradial procedures

16 July 2016
Author(s): Fabio Rigamonti, Baris Gencer, Florian Rey, Jawad Chaara, Elena Tessitore, Sholan Bunwaree, Pascal Meier, Stéphane Noble, Olivier Grosgurin, Robert Larribeau, Stephan Windecker, Federico Carbone, Fabrizio Montecucco, Nicolas Rodondi, Christian M. Matter, Thomas F. Luscher, François Mach, Marco Roffi

Transradial access (TRA) improves outcome compared with trans-femoral access for the management of patients with acute coronary syndromes. In this setting, it is unknown whether the activation of a... more

Early eradication has a lower risk of peptic ulcer bleeding in Helicobacter pylori-infected chronic kidney disease patients

19 July 2016
Author(s): Ching-Hui Hsu, Hsiao-Yun Hu, Nicole Huang, Shen-Shong Chang

End stage renal disease (ESRD) contributes to a higher mortality rate in peptic ulcer bleeding (PUB) patients. A crucial question is whether early Helicobacter pylori (H. pylori) eradication therapy... more

Prevalence and predictors of hyperprolactinemia in subclinical hypothyroidism

27 July 2016
Author(s): Lokesh Kumar Sharma, Neera Sharma, Adesh Kisanji Gadpayle, Deep Dutta

Hyperprolactinemia has been reported in 0–57% of primary hypothyroidism. Data on hyperprolactinemia in subclinical hypothyroidism (ScH) is scant and inconsistent. This study aimed to determine the... more

Review Article

Candidemia and invasive candidiasis in adults: A narrative review

6 July 2016
Author(s): Spinello Antinori, Laura Milazzo, Salvatore Sollima, Massimo Galli, Mario Corbellino

Candidemia and invasive candidiasis are major causes of morbidity and mortality, and their incidence is increasing because of the growing complexity of patients. Five species of Candida (Candida... more

The role of sodium intake in nephrolithiasis: epidemiology, pathogenesis, and future directions

19 July 2016
Author(s): Baris Afsar, Murat C. Kiremit, Alan A. Sag, Kayhan Tarim, Omer Acar, Tarik Esen, Yalcin Solak, Adrian Covic, Mehmet Kanbay

The prevalence of nephrolithiasis has doubled over the last decade and the incidence in females now approaches that of males. Since dietary salt is lithogenic, a purported mechanism common to both... more