Published: 13 April 2016
Author(s): Guang Wang, Jia Liu, Ning Yang, Yanjin Hu, Heng Zhang, Li Miao, Zhi Yao, Yuan Xu
Issue: April 2016
Section: Original Article

Fibroblast growth factor 21 (FGF21) is an important endogenous regulator of energy metabolism. Thyroid hormone has been shown to regulate hepatic FGF21 expression in rodents. The goal of this study was to evaluate the plasma FGF21 levels in participants with normal thyroid function, subclinical hypothyroidism, or overt hypothyroidism and to investigate the change of plasma FGF21 levels in patients with overt hypothyroidism after levothyroxine treatment.

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