Over the latest years, the incidence of West-Nile virus (WNV) infection has increased dramatically in some Italian regions, as in the North-east of Italy [1,2]. However, data regarding the prevalence of cardiovascular (CV) comorbidities and their potential impact on the short-term outcome of these patients have never been investigated. Generally, preexisting chronic conditions such as CV (CVD), metabolic and respiratory diseases are often associated with a greater risk of progression to a worst outcome.