Published: 13 February 2022
Author(s): Danila De Vito, Agostino Di Ciaula, Vincenzo O. Palmieri, Paolo Trerotoli, Angela Maria Vittoria Larocca, Maria Teresa Montagna, Piero Portincasa
Issue: April 2022
Section: Original article

COVID-19 pandemic has generated, to date, over 4.6 million deaths worldwide [1]. The high infection rate, however, is counterbalanced by variable clinical outcomes at the individual level. SARS-CoV-2 infection can lead to asymptomatic disease in a large number of subjects (about 40–45% of infections [2]) or to severe clinical presentations with systemic involvement, possibly causing death in the most vulnerable subjects.

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