April 2024

144 Articles

No Section

Exploring the Landscape of Familial Hypercholesterolemia: Unraveling Genetic Complexity and Clinical Implications

4 March 2024
Author(s): Fotios Barkas, Evangelos Liberopoulos, Manfredi Rizzo

Familial hypercholesterolaemia (FH) is the most encountered inherited metabolic disorder and is associated with premature cardiovascular disease.[1] Although early diagnosis is imperative for... more

Clinical Insights

Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology

22 April 2024
Author(s): Piero Portincasa, Gyorgy Baffy

The liver is affected by metabolic dysfunction, featuring variable degrees of steatosis, inflammation, liver cell injury, and fibrosis. Since alcohol can cause similar changes in the liver, this... more

Clopidogrel induced reduction in neutrophil count: An overlooked beneficial effect?

6 April 2024
Author(s): Stefano De Servi, Antonio Landi, Stefano Savonitto

Atherosclerosis is an inflammatory disease of the arteries with endothelial dysfunction favouring leukocytes recruitment into the arterial wall and ensuing lesion growth. The role of neutrophils has... more

Monkeypox infection, 18 months later: A vanishing epidemic?

17 February 2024
Author(s): F. Patauner, R. Gallo, E. Durante-Mangoni, L. Bertolino

On July 25, 2022, the World Health Organization (WHO) declared the Monkeypox (MPX) outbreak a ‘public health emergency of international concern’. Indeed, starting from May 2022, 92,783 cases have... more

Detection of subclinical atrial fibrillation with cardiac implanted electronic devices: What decision making on anticoagulation after the NOAH and ARTESiA trials?

27 January 2024
Author(s): Giuseppe Boriani, Luigi Gerra, Davide A Mei, Niccolo’ Bonini, Marco Vitolo, Marco Proietti, Jacopo F Imberti

Atrial fibrillation (AF) may be asymptomatic and the extensive monitoring capabilities of cardiac implantable electronic devices (CIEDs) revealed asymptomatic atrial tachi-arrhythmias of short... more

The lowest well tolerated blood pressure: A personalized target for all?

25 January 2024
Author(s): Paolo Verdecchia, Fabio Angeli, Gianpaolo Reboldi

Among the various clinical aspects related to the management of hypertension, the choice of blood pressure (BP) targets is probably one of the most challenging. Unfortunately, there is disagreement... more


Obesity phenotyping at the “heart” of risk stratification

13 April 2024
Author(s): Paolo Sbraccia

The recognition of obesity as a chronic disease is increasingly gaining consensus within the scientific community, supported by mounting evidence of its significant impact on overall morbidity and... more

When to prescribe oral anticoagulation for patients with device-detected subclinical atrial fibrillation? Insights from the NOAH-AFNET 6 and ARTESiA trials

9 April 2024
Author(s): William F. McIntyre, Jeffrey S. Healey, Renato D. Lopes

Device-detected, subclinical atrial fibrillation (AF), previously known as atrial high-rate episodes, is detected in roughly one-third of older patients with a pacemaker, defibrillator, or implanted... more

Pulmonary embolism: Put the sPESI into practice

9 April 2024
Author(s): David Jiménez

Since acute pulmonary embolism (PE) remains one of the leading causes of cardiovascular morbidity and mortality, the increased attention to risk prediction is well deserved [1]. Timely and accurate... more

Subclinical atrial fibrillation patients, who are the best candidates for oral anticoagulant therapy?

20 March 2024
Author(s): Bi Huang, David J. Wright, Gregory Y.H. Lip

Conventionally, atrial fibrillation (AF) is diagnosed by surface electrocardiogram (ECG) while cardiac implantable electronic devices (CIEDs) provides information of the cardiac electrical activity... more

Antibiotic shortages in Europe: Another question of prices?

16 March 2024
Author(s): L Garattini, B Finazzi, A Mazzone

Pharmaceutical shortages are currently a worldwide issue despite advancement in manufacturing and transport technologies [1]. Surprisingly, shortages still happen in many high-income countries too... more

Estimation of renal function: Different markers for different outcomes?

13 March 2024
Author(s): Claudio Pedone, Raffaele Antonelli Incalzi

Sarcopenia is a condition characterized by loss of muscle strength and mass that is strongly associated with age and age-related conditions, and is therefore considered a typically geriatric disease... more

Direct oral anticoagulants: The new standard of care for cancer associated thrombosis

8 March 2024
Author(s): Marcello Di Nisio, Agnes Y Lee

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), often complicates the course of cancer disease and represents an invariably distressing experience for... more

Action points for implementation of the lowest well-tolerated blood pressure

2 March 2024
Author(s): De-Wei An, Yan Li, Jan A. Staessen

In a seminal review of hypertension trials [1], Verdecchia and coworkers noticed that more intensive compared to usual blood pressure (BP) control reduced major cardiovascular complications (MACE),... more

Combining electrocardiographic and echocardiographic indexes to detect cardiac amyloidosis: A step forward in the quest to diagnose cardiac amyloidosis without delay

19 February 2024
Author(s): Steven A Muller, Hugh Calkins, Alessio Gasperetti

Cardiac amyloidosis (CA) is a progressive and life-threatening cardiomyopathy characterized by deposition of misfolded proteins in the myocardium, leading to heart failure (HF), conduction disorders... more

A call to action: The need to apply guidelines recommendations with ABC or SOS to improve stroke prevention and cardiovascular outcomes in patients with atrial fibrillation

2 February 2024
Author(s): Giuseppe Boriani, Enrico Tartaglia, Jacopo F. Imberti

Atrial fibrillation (AF) and stroke are deeply interlinked, as AF may precede ischemic stroke, thus being related to cardioembolism, but also manifest after both ischemic and hemorrhagic stroke [1].

Uncomplicated outpatient deep venous thrombosis management with a novel care pathway: Is it ready for prime time?

30 January 2024
Author(s): Alejandro Godoy, Stephanie Carlin, James D. Douketis

The standard-of-care for patients presenting to a general practitioner (GP) with suspected deep vein thrombosis (DVT) in many regions involves the use of a clinical decision rule and/or a d-dimer... more

Stressful experiences and venous thromboembolism

27 January 2024
Author(s): Arina ten Cate-Hoek, Hugo ten Cate

Despite stress being an accepted cause of arterial thrombotic events (ATE) [1,2], for which underlying pathophysiological processes have also been identified, it has not yet been widely recognised as... more


New horizons in the diagnosis and management of patients with MASLD

12 February 2024
Author(s): Karel J. van Erpecum, George N. Dalekos

The collection 'New horizons in the diagnosis and management of patients with metabolic dysfunction-associated steatotic liver disease (MASLD)’ that is presented here, deals with the natural history... more


Acute heart failure – an EFIM guideline critical appraisal and adaptation for internists

6 March 2024
Author(s): Valentin A. Kokorin, Alvaro González-Franco, Antonio Cittadini, Oskars Kalejs, Vera N. Larina, Alberto M. Marra, Francisco J. Medrano, Zdenek Monhart, Laura Morbidoni, Joana Pimenta, Wiktoria Lesniak

Over the past two decades, several studies have been conducted that have tried to answer questions on management of patients with acute heart failure (AHF) in terms of diagnosis and treatment.... more

Ideas and Opinions

What is disease modification and is this concept even helpful?

29 March 2024
Author(s): Maximilian Boesch, Florent Baty, Frank Rassouli, Martin H. Brutsche

An interesting session during a major scientific conference attended by the authors in fall 2023 discussed the concept of disease modification (DM). It became evident that DM is something that... more

Is full transparency in clinical trials an achievable goal?

8 March 2024
Author(s): Rafael Dal-Ré

In the last two decades several requirements have been developed to enhance clinical trials transparency. Some are encouraged or recommended by ethics codes, journal editors, or funders. Others are... more

Internal Medicine Flashcard

A man with darkened neck

5 March 2024
Author(s): Xin Nie, Zhixin Bie, Lin Li

A 65-year-old man presented with a 12-month history of gradual darkening of his neck. He also reported a progressive increased right side mandibular mass and a weight loss of 4 kg over 3 months. He... more

Gram staining of shoulder joint fluid

2 March 2024
Author(s): Yayoi Miyamatsu, Ryutaro Tanizaki

An 88-year-old Japanese man with Alzheimer's disease presented with fever that lasted for 1 day and arthralgia in the left shoulder. The patient had no history of trauma. On physical examination, his... more

Difficult to treat rheumatoid arthritis: Why profound differential diagnosis is important

28 February 2024
Author(s): Nils Schulz, Uwe Lange, Philipp Klemm

A 47-year-old patient was referred to our rheumatology department due to treatment refractory rheumatoid arthritis, characterized by polyarthralgia, progressive joint destruction, and impaired... more

A man with neurologic symptoms during liver abscess treatment

27 February 2024
Author(s): Yasuhiro Kano

An 84-year-old man was admitted for a pyogenic liver abscess and was treated with intravenous ceftriaxone and oral metronidazole 500 mg three times per day. The treatment proved effective; however,... more

A young man with amnesia after drug overdose

24 February 2024
Author(s): Dhairya A. Lakhani, Francis Deng

A 29-year-old man was found unconscious on the side of the road. Examination revealed pinpoint pupils and bradypnea. He regained consciousness after intranasal naloxone.

Pruritic papules and reticular pigmentation

19 February 2024
Author(s): Boyang Liu, Mengqi Lv, Jinbo Chen

A 21-year-old male with a previous history of good health. One month earlier, scattered, pruritic, red papules and maculopapules had developed on the chest and back. After papules fades, left light... more

Beau‘s lines in a man with lower limb burning sensation

17 February 2024
Author(s): Tsuyoshi Furuya, Yoshiaki Furukawa

A 49-year-old man presented with several months of burning sensation and numbness in the lower extremities. According to his statement of the medical history, there were no excessive drinking, intake... more

Internal Medicine Flashcards

An unexpected detour: Acute throat pain and trismus in a fast-food deliveryman

11 April 2024
Author(s): Hidenori Takahashi, Marino Fujisaki, Yuko Hata

A 40-year-old man fast-food deliveryman presented to the emergency department with a severe sore throat and trismus. His-symptoms rapidly escalated over 24 h, impairing his ability to speak, eat, and... more

Invited Review Article

Management of cardiovascular risk in patients with metabolic dysfunction-associated steatotic liver disease

25 November 2023
Author(s): Anders Mellemkjær, Mikkel Breinholt Kjær, David Haldrup, Henning Grønbæk, Karen Louise Thomsen

Non-alcoholic fatty liver disease (NAFLD) has for years been the most common liver disease worldwide. In 2016, the prevalence of NAFLD was estimated to be approximately 25 % [1], and recent reports... more

Letter to the Editor

Short-term trends in gastric cancer incidence after insurance coverage expansion for Helicobacter pylori eradication in Japan

22 April 2024
Author(s): Yusaku Kajihara

Helicobacter pylori (H. pylori) infection is a risk factor for gastric cancer (GC). The International Agency for Research on Cancer has recommended population-based screening and eradication of H.... more

Synergistic effect of spironolactone/ARB on cardiovascular endpoints in heart failure patients with preserved ejection

18 April 2024
Author(s): Xiao Liu, Yue Wang, Kaihang Yiu, Yuling Zhang, Jingfeng Wang

Currently, treatment options for HFpEF are limited. Several randomized controlled trials of RAAS inhibitors for HFpEF, including perindopril, candesartan, irbesartan, and spironolactone, have yielded... more

Effect of direct oral anticoagulants in patients with cerebral venous thrombosis

16 April 2024
Author(s): Ailin Li, Wengen Zhu, Xin Liu

Cerebral venous thrombosis (CVT) is a rare clotting disorder that mainly affects younger females. In order to achieve recanalization of cerebral veins and reduce the risk of venous thromboembolism (... more

‘Impact of Haemophilus spp. as a sexually transmitted disease’

15 April 2024
Author(s): Juan Gabriel Sánchez-Cano, Gonzalo Sierra-Torres, Laura Muñoz-Echeverría, Adriana Ortega-Fernández, María Velasco-Arribas

Despite the increasing prevalence of Haemophilus spp. isolates in urethral exudates in our health area, a city with more than 160,000 inhabitants in the south of Madrid, there are still uncertainties... more

The clinical spectrum of thymoma-associated immunodeficiency: Good syndrome and beyond

13 April 2024
Author(s): Chen Wang, Yiyun Shi, Xin Rong Lim, Jolan E. Walter

Good syndrome (GS) is an acquired adult-onset combined immunodeficiency typically characterized by thymoma and hypogammaglobulinemia. Other clinical manifestations include recurrent infections,... more

Interaction between age and efficacy of dual antiplatelet therapy in non-cardioembolic minor acute ischemic stroke or high-risk transient ischemic attack

9 April 2024
Author(s): Konstantinos G. Kyriakoulis, Ariadni Menti, Eleni Korompoki, George Ntaios, Anastasios Kollias

Short-term (21–90 days) dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel is recommended for patients with minor non-cardioembolic ischemic stroke [National Institutes of Health Stroke... more

Infective endocarditis complicated with heart failure

6 April 2024
Author(s): Baeza-Herrera Luis Augusto, Ruíz-Beltrán Arturo Maximiliano, Alvarado-Alvarado José Alfredo, González-Pacheco Héctor

Infective Endocarditis (IE) is a clinical entity with high morbidity and mortality despite advances in diagnosis and medical and surgical treatment alternatives. Globally, the prevalence is estimated... more

Resuming antiplatelet therapy in patients with intracranial hemorrhage

26 March 2024
Author(s): Asmaa Ahmed, Mohamed Hamed, Mona Mahmoud, Mamas A Mamas, Ayman Elbadawi, APICH

More than a third of adults who experience primary intracranial hemorrhage (ICH) in high-income countries are prescribed antiplatelet medications due to similar risk factors shared with vascular... more

Polyvalent immunoglobulin use: Issues between good use, economic constraints and shortages over 25 years

25 March 2024
Author(s): Q. Perrier, V. Tuloup, C. Chevallier-Brilloit, P. Bedouch, S. Chanoine, Polyvalent immunoglobulin group

Human normal polyvalent immunoglobulins (HNIg) have been widely used for the treatment of primary and secondary immune deficiencies. They also possess immunomodulatory properties and are employed in... more

A prediction model for differentiating recurrent Kawasaki disease from other febrile illnesses

24 March 2024
Author(s): Penghui Yang, Jing Zhang, Siqi Feng, Qijian Yi

Kawasaki disease (KD) can result in coronary artery aneurysms (CAA), elevating the risk of coronary artery thrombosis in the later stage [1]. Intravenous immunoglobulin within the first 10 days after... more

Long-term compliance of lipoprotein apheresis patients. What is health-related quality of life?

23 March 2024
Author(s): Beatrice Dal Pino, Carmen Corciulo, Andrea Ripoli, Federico Bigazzi, Francesco Sbrana

Clinical research and scientific evidence confirm the role of low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] as a risk factor for atherosclerosis and cardiovascular events.... more

Diagnosis traps for patients with acquired NLRP3 mutation

20 March 2024
Author(s): Margaux Cescato, Laurence Cuisset, Laurent Le Corre, Mathieu P Rodero, Sophie Georgin-Lavialle, on behalf of the F-CAPS study group

Cryopyrinopathies (cryopyrin-associated periodic syndrome, CAPS), also referred to as NLRP3 mutation-associated autoinflammatory diseases (NLRP3-AID), have historically been described as three... more

Changes in the Dynamic Trajectory of Remnant Cholesterol Affect the Occurrence of Nonalcoholic Fatty Liver Disease

14 March 2024
Author(s): Xinlei Miao, Manling Hu, Qianqian Wang, Guimin Tang, Song Leng

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, affecting approximately 20–25 % of the global adult population [1]. Epidemiological evidence showed that,... more

Patient-reported outcomes and apixaban therapy in older patients

11 March 2024
Author(s): Stefano Fumagalli, Giuseppe Di Pasquale, Simone Pupo, Giancarlo Agnelli, Niccolò Marchionni, APULEIO Study Investigators

Dear Editor

Chronic limb-threatening ischemia with no revascularization option: Result from a multidisciplinary care model

11 March 2024
Author(s): Davide Ceccato, Sonia Ragazzo, Francesca Boscaro, Giampiero Avruscio

Lower extremity chronic limb-threatening ischemia (CLTI) is the most advanced form of peripheral arterial disease (PAD). Historically, development of CLTI was associated with 1-year amputation rates... more

Development and validation of a clinical risk score for all-cause mortality in patients with acquired long QT syndrome

11 March 2024
Author(s): Xiaopeng Dong, Shihao Wang, Cheng Chen, Xiaolei Yang, Yunlong Xia

Dear editor,

Admission in Internal Medicine: The Italian issue

9 March 2024
Author(s): Antonino Mazzone, Nicola Montano

We appreciated the editorial by Garattini et al. [1], about the redesign of the Emergency and Urgency system in Europe. In relation to this argument, we would like to underline some critical aspects... more

Bleeding heralding the diagnosis of essential thrombocythemia

9 March 2024
Author(s): Grégoire Stalder, Francesco Grandoni, Lorenzo Alberio

We appreciate the opportunity to reply to the Letter to the Editor of Yang et al. [1], which refers to our recent publication [2] in order to present a case with a complementary clinical issue.

Minimally invasive puncture and drainage guided by 3D printed guide plate for the treatment of primary brain stem hemorrhage

8 March 2024
Author(s): Jun Shen, Quan Chen, Qiang Tong, Xiangyang Tian, Qiu Han

Primary brainstem hemorrhage manifests rapidly and is linked to poor prognosis, boasting a high fatality rate. It is an acute and lethal neurological disorder. With a hemorrhage volume exceeding 5 mL... more

Benefits and challenges of bronchoalveolar lavage in immunocompromised patients

8 March 2024
Author(s): Hiroshi Ito

Jahn K et al. conducted a prospective single-center observational study and found that treatment management changed in approximately half of the patients with immunocompromised lower respiratory... more

Effect of sodium-glucose cotransporter-2 inhibitors on pulmonary arterial wedge pressure

8 March 2024
Author(s): Paschalis Karakasis, Dimitrios Patoulias, George Giannakoulas, Stephan Rosenkranz, Nikolaos Fragakis

Several recent landmark trials have demonstrated that treatment with sodium–glucose cotransporter 2 inhibitors (SGLT2i) confers significant benefits to patients with heart failure (HF) and/or type 2... more

Impact of the timing of initial antibiotic administration on community-onset pneumonia hospital mortality

7 March 2024
Author(s): J. Vasco Barreto, Cláudia Camila Dias, Teresa Cardoso

Timely administration of appropriate antibiotics (ATB) is critical for treatment success in severe infections [1]. In clinical practice, early ATB administration in pneumonia is a common-sense... more

HbA1c% level patterns as a marker for malignancy in diabetic patients

6 March 2024
Author(s): Adi Rotkopf, Ela Giladi, Avishay Elis

Tumor-induced hypoglycemia is an uncommon phenomenon, usually resulting from insulin-secreting tumors [1]. However, it can also develop in other tumors, exclusively due to increased glucose... more

Effect of non-vitamin K oral anticoagulants for thrombosis prophylaxis in pediatric heart diseases

4 March 2024
Author(s): Hong Hong, Wengen Zhu, Zhongli Xie

Non-vitamin K oral anticoagulants (NOACs, namely dabigatran, rivaroxaban, apixaban, and edoxaban) have been widely recommended in preventing thromboembolic events among adult patients with atrial... more

Association between direct oral anticoagulants and risk of gastrointestinal bleeding

21 February 2024
Author(s): I-Wen Chen, Chia-Li Kao, Chun-Ning Ho, Kuo-Chuan Hung

We read with great interest the systematic review and meta-analysis by Kyriakoulis et al. comparing direct oral anticoagulants (DOACs) with vitamin K antagonists (VKAs) in patients with atrial... more

Role of emergency department physician in the management of osteoporotic fragility fractures in the elderly trauma patient

20 February 2024
Author(s): Tarik Wasfie, Holland Korbitz, Sara N. Nesheiwat, Jennifer Hille, Avery Jackson

Worldwide, half of females above the age of fifty years and 25 % of males over 65 years will sustain a fracture secondary to osteoporosis during their lifetime, with a refracture rate of 50 % in... more

Patient centered care: A multidisciplinary and holistic approach

20 February 2024
Author(s): Giovambattista Desideri, Nicola Montano, Giorgio Sesti

Modern medical care is increasingly underpinned by evidence-based guidelines which are widely viewed as a cornerstone of current efforts to define standards of care and improve the quality of... more

Outcomes of initial intravenous diuretic dose in acute heart failure

20 February 2024
Author(s): Houssam Bendoudouch, Badre El Boussaadani, Loubna Hara, Amine Ech-chenbouli, Zainab Raissouni

We would like to share with you the outcomes of our study revolving around the routine use of diuretics in acute heart failure (AHF). The topic is of great interest, and although many studies and... more

The impact of sodium-glucose cotransporter-2 inhibitors on cardiac function

19 February 2024
Author(s): I-Wen Chen, Hsiu-Lan Weng, Kuo-Chuan Hung

Dear Editor,

Comparing the risk of dementia in patients with atrial fibrillation taking different oral anticoagulants

17 February 2024
Author(s): Sheng-Feng Sung, Hsin-Yi Yang, Ching-Fang Tsai, Chen-Wen Fang

Dear editor,

Efficacy and safety of eplerenone in heart failure management

15 February 2024
Author(s): Jin Zheng, Shuangao Wang, Ana Teresa Timóteo

Dear Editor,

Prevalence of post-COVID symptoms one-year after SARS-CoV-2 infection in patients with interstitial lung disease

6 February 2024
Author(s): Paula Parás-Bravo, César Fernández-de-las-Peñas, Diego Ferrer-Pargada, Sheila Izquierdo-Cuervo, Manuel Herrero-Montes

The Global Burden of Disease Study revealed that chronic respiratory diseases remain to be leading cause of death and disability worldwide [1]. In the recent years, the world has experienced a... more

MEFV gene mutation (c.229G>T) as a cause of fever of unknown origin

5 February 2024
Author(s): Jose Pablo Miramontes-González, Andreea Catalina Cristea, Miriam Gabella Martín, María González Fernández, José Luis Pérez-Castrillón

Fever of unknown origin (FUO) was traditionally characterized by a temperature exceeding 38.3 °C on at least three occasions over a period of at least three weeks, with no apparent cause despite one... more

ACE inhibitors and lung cancer: There is more to it than just a cough

3 February 2024
Author(s): Muhammad Ahmad, Malik Waleed Zeb Khan, Shandana Ali, Salman Khan, Shakir Ullah

We are writing to highlight the findings of a recent meta-analysis suggesting a possible relationship between the long-term use of angiotensin-converting enzyme inhibitors (ACEIs) and an increased... more

Efficacy of canakinumab for mosaic tumor necrosis factor receptor associated periodic syndrome

2 February 2024
Author(s): Alexandre Terré, Mathieu Vautier, Jean-Emmanuel Kahn, Sophie Georgin-Lavialle, Guilaine Boursier

Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS) is one of the first monogenic autoinflammatory diseases to be described [1]. TRAPS is a dominant disease due to mutations in the... more

Longitudinal trends in acute pulmonary embolism hospitalizations during the COVID-19 pandemic

2 February 2024
Author(s): Agam Bansal, Aravinda Nanjundappa, Daniel Raymond, Lee Kirksey, Umesh N. Khot

Existing studies have illustrated that the coronavirus disease 2019 (COVID-19) infection is an independent risk factor for pulmonary embolism (PE) [1–4]. However, longitudinal trends in incidence of... more

Histopathological necrotizing vasculitis predicts severe flare of eosinophilic granulomatosis with polyangiitis

31 January 2024
Author(s): Eisuke Takamasu, Naoto Yokogawa, Haruka Okada, Ryo Morishima, Kota Shimada

Dear Editor, eosinophilic granulomatosis with polyangiitis (EGPA) is histologically defined by eosinophil-rich, necrotizing granulomatous inflammation primarily involving the respiratory tract along... more

Difficult to treat rheumatoid arthritis: Sequential therapy with different personalized biological targets could be an option

31 January 2024
Author(s): Elisa Gremese, Dario Bruno, György Nagy, Gianfranco Ferraccioli

Difficult to treat (D2T) rheumatoid arthritis (RA) is considered a clinical setting that physicians already label as very complicated to address from a therapeutic point of view for various reasons [... more

Prognostic value of paradoxical pulsation after acute anterior myocardial infarction

27 January 2024
Author(s): Bing-Hua Chen, Hui Tang, Dong-Aolei An, Jun Pu, Lian-Ming Wu

After acute anterior myocardial infarction, most patients displayed paradoxical pulsation (the paradoxical expansion of left ventricular infarct segments), which is easily complicated by early... more

Previously undiagnosed asymptomatic peripheral arterial disease in patients undergoing coronary angiography

23 January 2024
Author(s): Sohaib Ashraf, Amir Shahbaz, Maryam Ashraf, Wasim Ibrahim, Qazi Abdul Saboor

Atherosclerosis plays a significant role in developing coronary artery disease (CAD), peripheral artery disease (PAD), and cerebrovascular disease. Atherosclerotic plaque rupture provokes... more

Bone infarction: A rare complication of essential thrombocytosis with JAK2-V617F mutation

19 January 2024
Author(s): Yun Yang, Yanjun Ren, Kaining Zhang, Meng Chen, Changjun Chen

We read with great interest the article by Yang et al., published in the European Journal of Internal Medicine [1]. We appreciate their great work. In addition to the finding that JAK2-V617F-mutated... more

Kidney function and sarcopenia: A risk assessment

19 January 2024
Author(s): Tomoyuki Kawada

I read with great interest the paper by Moreno-González et al. [1], who investigated the association between sarcopenia and kidney function in older adults, aged ≥75 years. Estimated glomerular... more

Treatment with direct oral anticoagulants (DOACs) and secondary prophylaxis in patients affected by multiple episodes of superficial venous thrombosis

19 January 2024
Author(s): Alessandro Laganà, Silvia Sorella, Ludovica Fucci, Angelo Genoese, Antonio Chistolini

Superficial vein thrombosis (SVT) describes partial or total thrombotic lumen obstruction of a superficial vein and inflammatory alterations of the affected vessel wall [1]. The precise incidence of... more

Thrombocytopenia and bleeding events in patients with venous thromboembolism

17 January 2024
Author(s): Shinya Ito, Moriaki Inoko, Yugo Yamashita, Takeshi Morimoto, Takeshi Kimura, COMMAND VTE Registry-2 Investigators

Thrombocytopenia is a prevalent blood abnormality, especially in elderly patients or those with cancer [1], and could increase the risk of anticoagulation-associated bleeding. However, there is a... more

Imaging of lung structure destruction for predictive diagnosing acute exacerbation of chronic obstructive lung disease complicated with pulmonary thromboembolism or pulmonary thrombosis in situ

16 January 2024
Author(s): Dawen Wu, Shimou Chen, Yunchang Pan, Rongzhang Liang, Chaosheng Deng, COPD and PTE Study Group

Chronic obstructive lung disease (COPD) is an independent risk factor for pulmonary thromboembolism (PTE), which often originates from deep vein thrombosis (DVT) and is a common comorbidity [1].... more

Machine learning models for the early prediction of ventilator-associated pneumonia

30 December 2023
Author(s): Liqi Li

We read with interest the article by Frondelius et al. entitled ‘Early prediction of ventilator-associated pneumonia with machine learning models: A systematic review and meta-analysis of prediction... more

Combined guidance of fluoroscopy and transthoracic echocardiography for endomyocardial biopsy

30 December 2023
Author(s): Yin-Jian Yang, Fan Guo, Lu-Hong Qiu, Xi-Qi Xu, Zhi-Cheng Jing

Endomyocardial biopsy (EMB) is important in revealing the aetiology of cardiac disorders for individuals in whom non-invasive approaches are insufficient to gather a correct diagnosis, as well as in... more

Don't ignore the internists; Who do you think holds the holy grail?

29 December 2023
Author(s): Oğuz Abdullah Uyaroğlu

Recently a new paradigm, cardiovascular-kidney-metabolic (CKM) syndrome, has been defined by the American Heart Association (AHA) as a health problem due to connections among diabetes, kidney disease... more

Original Article

Serum IL-6 level trajectory for predicting the effectiveness and safety of tocilizumab in the treatment of refractory Takayasu arteritis

21 April 2024
Author(s): Xiaochuan Sun, Chenglong Fang, Shangyi Jin, Jing Li, Yunjiao Yang, Xiaofeng Zeng, Xinping Tian

Takayasu arteritis (TAK) is a chronic systemic granulomatous vasculitis that mainly affects aorta and its major branches in young women [1]. The inflammatory damage of arteries can develop... more

Cardio-protective effects of statins in patients undergoing anthracycline-based chemotherapy: An updated meta-analysis of randomized controlled trials

19 April 2024
Author(s): Nicole Felix, Paula C. Nogueira, Isadora M. Silva, Thomaz Alexandre Costa, Carlos Alberto Campello, Carlos Stecca, Renato D. Lopes

Cancer and cardiovascular disease are two leading causes of mortality worldwide, and cancer survivors have an increased cardiovascular risk due to shared risk factors with cardiovascular disease and... more

Prognostic value of 18 FDG-PET at diagnosis and follow-up in giant cell arteritis: An observational restrospective study

15 April 2024
Author(s): Anne-Claire Billet, Thomas Thibault, Éric Liozon, Hubert De Boysson, Laurent Perard, Olivier Espitia, Aurélie Daumas, Quentin Gomes De Pinho, Cécile-Audrey Durel, Arnaud Hot, Boris Bienvenu, Sébastien Humbert, Claude Bachmeyer, Sabine Mainbourg, Thomas Sené, Hervé Devilliers, Bastien Durand Bailloud, Hélène Greigert, Alexandre Cochet, Bernard Bonnotte, Jean-Louis Alberini, Maxime Samson, French Study Group for Large Vessel Vasculitis (GEFA)

To evaluate the ability of 18FDG PET/CT, at diagnosis of giant cell arteritis (GCA) and during follow-up, to predict occurrence of relapse in large-vessel GCA (LV-GCA).

Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score

15 April 2024
Author(s): Roberto Bernabéu-Mora, Silvana Loana Oliveira-Sousa, Francesc Medina-Mirapeix, Mariano Gacto-Sánchez, Group of Investigation SAQ_COPD

Chronic obstructive pulmonary disease (COPD) is a heterogeneous and systemic condition characterized by chronic respiratory symptoms (dyspnea, cough, sputum production) due to abnormalities of the... more

Prognostic impact of hypertension grading

14 April 2024
Author(s): Fabio Angeli, Paolo Verdecchia, Gianpaolo Reboldi

Notwithstanding the continuous relation between blood pressure (BP) and the risk of cardiovascular disease [1,2], Guidelines generally grade hypertension in untreated subjects by arbitrary categories... more

Prognostic value of cognitive impairment, assessed by the Clock Drawing Test, in emergency department patients presenting with non-specific complaints

10 April 2024
Author(s): Tanguy Espejo, Nadja Wagner, Henk B. Riedel, Julia Karakoumis, Nicolas Geigy, Christian H. Nickel, Roland Bingisser

Cognitive impairment (CI) is common among older patients presenting to the emergency department (ED) [1–6]. Up to 40% of older ED patients have some degree of CI at presentation, particularly due to... more

Clinical significance of the anti-Nucleolar Organizer Region 90 antibodies (NOR90) in systemic sclerosis: Analysis of the European Scleroderma Trials and Research (EUSTAR) cohort and a systematic literature review

9 April 2024
Author(s): A Dima, MC Vonk, A Garaiman, BE Kersten, R Becvar, M Tomcik, A-M Hoffmann-Vold, I Castellvi, JL Tandaipan Jaime, M Brzosko, M Milchert, D Krasowska, M Michalska-Jakubus, P Airo, M Matucci-Cerinic, C Bruni, M Iudici, JHW Distler, AM Gheorghiu, H Poormoghim, F Motta, M De Santis, M Parvu, O Distler, C Mihai

The anti-Nucleolar Organizer Region 90 antibodies (NOR90) are rare antinuclear antibodies (ANA) reported in systemic sclerosis (SSc). Especially due to low prevalence, the clinical relevance of NOR90... more

Evolution and outcomes of aortic dilations in giant cell arteritis

5 April 2024
Author(s): Sophie Gallou, Christian Agard, Anael Dumont, Samuel Deshayes, Jonathan Boutemy, Gwénola Maigné, Nicolas Martin Silva, Alexandre Nguyen, Rémi Philip, Olivier Espitia, Achille Aouba, Hubert de Boysson

Giant cell arteritis (GCA) is a systemic vasculitis that typically affects large and medium vessels in patients over 50 years of age [1–3]. In addition to the cephalic presentation mainly explained... more

Relation of plasma neuropeptide-Y with myocardial function and infarct severity in acute ST-elevation myocardial infarction

29 March 2024
Author(s): Christina Tiller, Martin Reindl, Magdalena Holzknecht, Ivan Lechner, Felix Troger, Fritz Oberhollenzer, Sebastian von der Emde, Thomas Kremser, Agnes Mayr, Axel Bauer, Bernhard Metzler, Sebastian J Reinstadler

Acute myocardial infarction is associated with high levels of cardiac sympathetic stimulation [1], which is strongly related to poor outcome [2]. Prolongation of this sympathetic drive leads to the... more

The interplay between subclinical hypothyroidism and poor sleep quality: A systematic review

28 March 2024
Author(s): Marsida Teliti, Francesco Fanfulla, Laura Croce, Francesca Coperchini, Mario Rotondi

Sleep and the hypothalamic-pituitary-thyroid (HPT) axis show a mutual interdependence in normal physiological functioning [1]. While the interconnection between overt hypo- and hyperthyroidism and... more

Serum potassium abnormalities, renin-angiotensin-aldosterone system inhibitor discontinuation, and clinical outcomes in patients with chronic cardiovascular, metabolic, and renal conditions: A population-based analysis

27 March 2024
Author(s): Santiago Jiménez-Marrero, Miguel Cainzos-Achirica, David Monterde, Emili Vela, Cristina Enjuanes, Sergi Yun, Alberto Garay, Pedro Moliner, Miriam Corbella, Sílvia Jovells-Vaqué, Lídia Alcoberro, Alexandra Pons-Riverola, Raul Ramos-Polo, Herminio Morillas, Joan Antoni Gómez-Hospital, Josep Comin-Colet

The inhibition of the renin-angiotensin-aldosterone system (RAAS) is a essential aspect of the medical treatment of several chronic cardiovascular, metabolic, and renal conditions. It plays a vital... more

Sex-based differences in the comprehensive geriatric assessment in elderly hospitalized patients with non-valvular atrial fibrillation

27 March 2024
Author(s): Giuseppe Armentaro, Daniele Pastori, Alberto Castagna, Valentino Condoleo, Velia Cassano, Carlo Alberto Pastura, Mattea Francica, Caterina Benincasa, Nicola D'Alterio, Franco Arturi, Giovanni Ruotolo, Angela Sciacqua

Atrial fibrillation (AF) represents the most common supraventricular arrhythmia in elderly [1]. It was estimated that 1 % to 3 % of the world population suffers from AF, with higher prevalence in the... more

The correlation of atherogenic index of plasma with non-obstructive CAD and unfavorable prognosis among patients diagnosed with MINOCA

26 March 2024
Author(s): Fuad A. Abdu, Jiasuer Alifu, Abdul-Quddus Mohammed, Lu Liu, Wen Zhang, Guoqing Yin, Xian Lv, Ayman A. Mohammed, Redhwan M. Mareai, Yawei Xu, Wenliang Che

Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a complex and intriguing phenomenon with diverse underlying pathophysiological mechanisms that challenge conventional... more

Recurrence of hypertriglyceridemia-associated acute pancreatitis: A multicenter, prospective cohort study

26 March 2024
Author(s): Ling Ding, Shuai Li, Longxiang Cao, Lanting Wang, Jing Zhou, Wenjian Mao, Weiqin Li, Yin Zhu, Lu Ke, the Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG)

Hypertriglyceridemia (HTG) is a well-established etiology of acute pancreatitis (AP), accounting for approximately 4.7–14.3 % of all cases globally [1,2]. Recurrent acute pancreatitis (RAP) is one of... more

Safety and compliance of long-term low-dose ondansetron in alcohol use disorder treatment.

23 March 2024
Author(s): Giovanni Addolorato, Hannu Alho, Paula Bresciani M․ De Andrade, Otto Michael Lesch, Lei Liu, Bankole Johnson

There are geographical differences regarding alcohol-associated morbidity and mortality, the WHO European Region being the most affected area [1]. Europe leads globally in per capita alcohol... more

Visit-to-visit blood pressure variability is associated with intrinsic capacity decline: Results from the MAPT Study

18 March 2024
Author(s): Leonardo Bencivenga, Mathilde Strumia, Yves Rolland, Sophie Guyonnet, Angelo Parini, Philippe Cestac, Sandrine Andrieu, Philipe De Souto Barreto, Laure Rouch, For the MAPT/DSA group

Blood Pressure (BP) values fluctuate over time around average values, as a consequence of the interaction between multiple intrinsic and environmental factors affecting the cardiovascular system [1... more

Early and accurate diagnosis of steatotic liver by artificial intelligence (AI)-supported ultrasonography

14 March 2024
Author(s): Sergio Santoro, Mohamad Khalil, Hala Abdallah, Ilaria Farella, Antonino Noto, Giovanni Marco Dipalo, Piercarlo Villani, Leonilde Bonfrate, Agostino Di Ciaula, Piero Portincasa

Nonalcoholic fatty liver disease (NAFLD) refers to liver steatosis, i.e., over-storage of fat, mainly triglycerides, in the hepatocytes, without other causes for secondary hepatic fat accumulation [1... more

Risk prediction of major cardiac adverse events and all-cause death following covid-19 hospitalization at one year follow-up: The HOPE-2 score

11 March 2024
Author(s): Francesco Santoro, Ivan J. Núñez-Gil, María C. Viana-Llamas, Emilio Alfonso-Rodríguez, Aitor Uribarri, Victor Manuel Becerra-Muñoz, Gisela Feltes Guzman, Nicola Di Nunno, Javier Lopez-Pais, Enrico Cerrato, Gianfranco Sinagra, Massimo Mapelli, Riccardo M. Inciardi, Claudia Specchia, Chiara Oriecuia, Natale Daniele Brunetti

COVID-19 is an infectious disease that has become pandemic from 2020. Data on acute outcome, showed that among hospitalized patients mortality rates were 15.8 % in USA[1] and 22 % in Europe [2,3].... more

Prognosis of COVID-19 severity using DERGA, a novel machine learning algorithm

8 March 2024
Author(s): Panagiotis G. Asteris, Amir H. Gandomi, Danial J. Armaghani, Styliani Kokoris, Anastasia T. Papandreadi, Anna Roumelioti, Stefanos Papanikolaou, Markos Z. Tsoukalas, Leonidas Triantafyllidis, Evangelos I. Koutras, Abidhan Bardhan, Ahmed Salih Mohammed, Hosein Naderpour, Satish Paudel, Pijush Samui, Ioannis Ntanasis-Stathopoulos, Meletios A. Dimopoulos, Evangelos Terpos

The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the novel coronavirus Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2), has had a profound impact on healthcare systems... more

Cardiometabolic risk stratification using a novel obesity phenotyping system based on body adiposity and waist circumference

6 March 2024
Author(s): Javier Gómez-Ambrosi, Victoria Catalán, Beatriz Ramírez, Laura Salmón-Gómez, Rocío Marugán-Pinos, Amaia Rodríguez, Sara Becerril, Maite Aguas-Ayesa, Patricia Yárnoz-Esquíroz, Laura Olazarán, Carolina M. Perdomo, Camilo Silva, Javier Escalada, Gema Frühbeck

Over the past decades, obesity has been increasingly prevalent throughout the world. Between 1975 and 2014, the prevalence of obesity in adults, defined as a body mass index (BMI) ≥30 kg/m²,... more

Personalized decision support system for tailoring IgA nephropathy treatment strategies

4 March 2024
Author(s): Jiaxing Tan, Rongxin Yang, Liyin Xiao, Yuanlin Xia, Wei Qin

Immunoglobulin A nephropathy (IgAN), considered the most prevalent form of primary glomerular disease worldwide, is characterized by the deposition of IgA in the mesangial area of the glomeruli and... more

Comparison of diagnostic spectrum between inflammation of unknown origin and fever of unknown origin: A systematic review and meta-analysis

1 March 2024
Author(s): Albrecht Betrains, Lien Moreel, Catharina M. Mulders-Manders, Paul G. Auwaerter, Joaquim Torné-Cachot, Friedrich Weitzer, Teruhiko Terasawa, Kim H. Ly, Verena Schönau, Daniel Blockmans, William F. Wright, Chantal Rovers, Steven Vanderschueren

Fever of unknown origin (FUO) and inflammation of unknown origin (IUO) are two clinical syndromes that are separated by an arbitrary temperature threshold. They share a common spectrum of underlying... more

TSLP is localized in and released from human lung macrophages activated by T2-high and T2-low stimuli: relevance in asthma and COPD

24 February 2024
Author(s): Luisa Canè, Remo Poto, Francesco Palestra, Marinella Pirozzi, Seetharaman Parashuraman, Ilaria Iacobucci, Anne Lise Ferrara, Antonello La Rocca, Edoardo Mercadante, Piero Pucci, Gianni Marone, Maria Monti, Stefania Loffredo, Gilda Varricchi

The human lung is a remarkable organ that filters up to 10,000 liters of air daily, interfacing with the exposome [1]. Several environmental factors, including airborne pollutants, particulate matter... more

Primary Sjögren's syndrome in Italy: Real-world evidence of a rare disease through administrative healthcare data

17 February 2024
Author(s): Giacomo Cafaro, Carlo Perricone, Giulia Ronconi, Silvia Calabria, Letizia Dondi, Leonardo Dondi, Antonella Pedrini, Immacolata Esposito, Roberto Gerli, Elena Bartoloni, Nello Martini

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease with a protean clinical phenotype ranging from very mild manifestations of dry eye and dry mouth to life-threatening major... more

Performance of the Simplified Pulmonary Embolism Severity Index in predicting 30-day mortality after acute pulmonary embolism: Validation from a large-scale cohort

12 February 2024
Author(s): Yu Zhang, Yinong Chen, Hong Chen, Chunling Dong, Xiaoyun Hu, Xiaomao Xu, Ling Zhu, Zhe Cheng, Dingyi Wang, Zhu Zhang, Wanmu Xie, Jun Wan, Peiran Yang, Shengfeng Wang, Chen Wang, Zhenguo Zhai, CURES investigators

Acute pulmonary embolism (PE) can be life-threatening in certain situations. Recent epidemiological data suggest that PE can affect approximately 300,000 patients and may result in 60,000 to 100,000... more

Impact of early initiation of ezetimibe in patients with acute coronary syndrome: A systematic review and meta-analysis

9 February 2024
Author(s): Kunal Mahajan, Lakshmi Nagendra, Anil Dhall, Deep Dutta

Patients with acute coronary syndrome (ACS) are at maximal risk of recurrent events in the initial few weeks following the index coronary event, with some studies suggesting that the risk may be as... more

The yield of total body CT in the workup of fever of unknown origin in hospitalized medical patients

1 February 2024
Author(s): Jacob David Miller, Naomy Moskovich, Lior Nesher, Victor Novack

A fever of an Unknown Origin (FUO) is defined as a rectal temperature above 38.3 on at least two occasions with an illness duration of over three weeks and no apparent cause after one week of... more

The usefulness of 18F-FDG-PET/CT in detecting musculoskeletal and vascular involvement in patients with polymyalgia rheumatica receiving glucocorticoids

31 January 2024
Author(s): Ana Serrano-Combarro, Diana Prieto-Peña, Isabel Martínez-Rodríguez, Néstor Martínez-Amador, Javier Loricera, Ricardo Blanco

Polymyalgia rheumatica (PMR) is a relatively common disease among European patients older than 50 years [1]. It is an inflammatory disorder characterized by severe pain and stiffness affecting mainly... more

Neurological hypertensive emergencies: Correlation of blood pressure values with in-hospital outcomes in ischemic stroke

30 January 2024
Author(s): Valentina Giani, Tommaso Valobra, Nicolò Capsoni, Michele Galasso, Lorenzo De Censi, Cecilia Ferretti, Andrea Sultana, Annalisa Giacalone, Ilaria Garofani, Michele Bombelli, Chiara Ceresa, Silvia Gheda, Elio Clemente Agostoni, Filippo Galbiati, Cristina Giannattasio, Alessandro Maloberti

Few certainties exist regarding optimal management of Blood Pressure (BP) in the very first hours after an ischemic stroke and many questions remain still unanswered. Our work aimed to evaluate the... more

Osteonecrosis risk after steroids-related treatment of COVID-19 is not negligible: A cross sectional study

27 January 2024
Author(s): Antonios A. Koutalos, Alexandros Koskiniotis, Christos Rountas, Efstathios Konstantinou, Sarah Georgiadou, Aggelos Stefos, Nikolaos K. Gatselis, George N. Dalekos, Konstantinos N. Malizos

Osteonecrosis is a common complication after steroid treatment for various etiologies more frequently affecting the hip, but also the humeral head, the knee, and the ankle joints [1]. Due to the... more

Transition of management strategies and long-term outcomes in cancer-associated venous thromboembolism from the warfarin era to the direct oral anticoagulant era

25 January 2024
Author(s): Ryuki Chatani, Yugo Yamashita, Takeshi Morimoto, Kazuhisa Kaneda, Kazunori Mushiake, Kazushige Kadota, Yuji Nishimoto, Nobutaka Ikeda, Yohei Kobayashi, Satoshi Ikeda, Kitae Kim, Moriaki Inoko, Toru Takase, Shuhei Tsuji, Maki Oi, Takeshi Kimura, COMMAND VTE Registry-2 Investigators

Cancer remains a progressive disease with a high mortality despite of multidisciplinary treatment. However, many patients with cancer have recently been living longer owing to advancement in early... more

Post-cardiac injury syndrome and pericardial effusion recurrence after pericardial effusion drainage in chronic idiopathic pericardial effusion

22 January 2024
Author(s): Edoardo Conte, Silvia Tamanini, Emanuele Bizzi, Silvia Maestroni, Davide Cumetti, Maria Laura Novembre, Gianfranco Lauri, Cecilia Agalbato, Alessia Dalla Cia, Pasquale Paolisso, Gianluca Pontone, Mauro Pepi, Daniele Andreini, Massimo Imazio, George Lazaros, Alberto Benetti, Antonio Brucato

Chronic pericardial effusion in the absence of pericardial inflammation often represents both a diagnostic and management dilemma. Although pericardial effusion drainage should be promptly performed... more

Genetic heterogeneity of familial hypercholesterolaemia in two populations from two different countries

19 January 2024
Author(s): Asiiat Alieva, Alessia Di Costanzo, Marta Gazzotti, Olga Reutova, Elena Usova, Viktoria Bakaleiko, Marcello Arca, Laura D'Erasmo, Fabio Pellegatta, Federica Galimberti, Elena Olmastroni, Alberico L Catapano, Manuela Casula

Familial hypercholesterolemia (FH) (MONDO:0007750) is a genetically determined monogenic disorder of predominantly autosomal dominant inheritance, which leads to a significant increase in low-density... more

A systematic literature review of randomised controlled trials evaluating colchicine for cardiovascular prevention: There is an elephant in the room

2 January 2024
Author(s): Alessia Alunno, Francesco Carubbi, Cecilia Martini, Veronica Moronti, Jessica Santilli, Jan W Schoones, Francesco Maria Mariani, Evy Di Ruscio, Piera Altieri, Claudio Ferri

Gout is a chronic inflammatory disease burdened by a higher CV risk compared to the general population [1] and this excess risk cannot be explained only by the prevalence of traditional risk factors... more

Deferring diagnostic evaluation for suspected deep venous thrombosis using a single dose of anticoagulant: Real-world data from a regionwide care pathway

26 December 2023
Author(s): Inge H.Y. Luu, Guy J.M. Mostard, Dominique van Mil, Marlon H.W. van Berlo, Marc B.I. Lobbes, Kemal Külcü, Hugo ten Cate, Jos Peeters, Jan Palmen, Jacqueline Buijs, Kon-Siong G. Jie, Roel J.W. van Kampen, Daan J.L. van Twist

Timely diagnosis and treatment of deep venous thrombosis (DVT) are crucial to prevent potential life-threatening complications, such as pulmonary embolism (PE). As DVT cannot be reliably excluded... more

Intimate partner violence as a risk factor for venous thromboembolism in women on combined oral contraceptives: An international matched case-control study

21 December 2023
Author(s): Mathias Chéa, Chloé Bourguignon, Sylvie Bouvier, Eva Nouvellon, Jeremy Laurent, Antonia Perez-Martin, Eve Mousty, Sylvie Ripart, Mariya Gennadevna Nikolaeva, Jamilya Khizroeva, Victoria Bitsadze, Alexander Makatsariya, Jean-Christophe Gris

Venous thromboembolism (VTE), deep vein thrombosis (DVT) and/or pulmonary embolism (PE) is a rare event in women of childbearing age, affecting 2–10/10,000 persons per year [1]. Exogenous sex... more

Thyroid and adrenal incidentalomas on chest CT: Prevalence, diagnostic work-up and outcomes in a cohort of COVID-19 suspected patients

20 December 2023
Author(s): Jeresa I.A. Willems, Roderick F.A. Tummers-de Lind van Wijngaarden, Ivo J.M. Dubelaar, Martijn D. De Kruif, Math P.G. Leers, Inge H.Y. Luu, Robin P. Peeters, Daan J.L. van Twist

Thyroid and adrenal incidentalomas are commonly detected on computed tomography (CT) imaging. Due to the increased use of advanced CT imaging prevalence rates are still rising, leading to an ‘... more

Adherence to an integrated care pathway for stroke is associated with lower risk of major cardiovascular events: A report from the Athens Stroke Registry

15 December 2023
Author(s): Dimitrios Sagris, Gregory Υ Η Lip, Eleni Korompoki, George Ntaios, Konstantinos Vemmos

Despite improvements in overall stroke survival, patients surviving an ischaemic stroke are at increased risk of cardiovascular complications, both in the acute and chronic phase, and one-third of... more

Kidney function and other associated factors of sarcopenia in community-dwelling older adults: The SCOPE study

15 December 2023
Author(s): Rafael Moreno-González, Josep Maria Cruzado, Andrea Corsonello, Paolo Fabbietti, Lisanne Tap, Francesco Mattace-Raso, Johan Ärnlöv, Axel C. Carlsson, Agnieszka Guligowska, Tomasz Kostka, Rada Artzi-Medvedik, Itshak Melzer, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Robert Kob, Cornel Sieber, Fabrizia Lattanzio, Francesc Formiga, SCOPE investigators

Sarcopenia has been drawing growing attention in recent years, with a rapidly increasing number of research studies being performed in this field. The establishment of an International Classification... more

Features of immune mediated diseases in JAK2 (V617F)-positive myeloproliferative neoplasms and the potential therapeutic role of JAK inhibitors

2 December 2023
Author(s): Carmen Álvarez-Reguera, Diana Prieto-Peña, Alba Herrero-Morant, Lara Sánchez-Bilbao, Ana Batlle-López, Sara Fernández-Luis, Nerea Paz-Gandiaga, Ricardo Blanco

The Janus Kinase (JAK) 2 (V617F) mutation is the most frequently detected in myeloproliferative neoplasms (MPN). JAK2(V617F) mutation displays a pro-inflammatory phenotype that may be associated to a... more

Chronic thromboembolic pulmonary disease: Association with exercise-induced pulmonary hypertension and right ventricle adaptation over time

1 December 2023
Author(s): Rosalinda Madonna, Mattia Alberti, Filippo Biondi, Riccardo Morganti, Roberto Badagliacca, Carmine Dario Vizza, Raffaele De Caterina

Chronic thromboembolic pulmonary disease (CTEPD) [1] is a newly described disease entity belonging to a broader group of diseases affecting the pulmonary arterial vasculature as a result of PE [1,2... more

Relation between high-sensitivity troponin I serum levels and myocardial ischemia in patients with suspected chronic coronary syndrome: The RESET-MI study

23 November 2023
Author(s): Antonio De Vita, Isabella Bruno, Silvia Baroni, Giacomo Moretti, Federica Tempestini, Alessandro Telesca, Saverio Tremamunno, Tamara Felici, Alfonso Verrillo, Valeria Tempesta, Vanessa Feudo, Priscilla Lamendola, Giovanna Liuzzo, Filippo Crea, Alessandro Giordano, Gaetano Antonio Lanza

The detection of increased serum levels of cardiac troponins in a clinical context of acute myocardial ischemia is a crucial finding for the diagnosis of acute myocardial infarction (AMI) [1,2].... more

Muscularity and adiposity are differently associated with inflammatory and nutritional biomarkers among patients on hemodialysis and peritoneal dialysis

18 November 2023
Author(s): Alessio Molfino, Giovanni Imbimbo, Orietta Picconi, Lida Tartaglione, Maria Ida Amabile, Silvia Lai

Changes in body composition, in particular in terms of distribution and quantity of adiposity and low muscularity, have been frequently observed in end-stage renal disease (ESRD) and associated with... more

Long non-coding RNAs H19 and NKILA are associated with the risk of death and lacunar stroke in the elderly population

18 November 2023
Author(s): Tetiana Lapikova-Bryhinska, Stefano Ministrini, Yustina M. Puspitasari, Simon Kraler, Shafeeq Ahmed Mohamed, Sarah Costantino, Francesco Paneni, Michael Khetsuriani, Susan Bengs, Luca Liberale, Fabrizio Montecucco, Wolfgang Krampla, Peter Riederer, Margareta Hinterberger, Peter Fischer, Thomas F. Lüscher, Edna Grünblatt, Alexander Akhmedov, Giovanni G. Camici

Aging is a multifaceted biological process characterized by a progressive decline in physiological function and increased vulnerability to various diseases [1]. It is associated with multiple... more

Prognostic role of mitral regurgitation in patients with advanced heart failure

17 November 2023
Author(s): Matteo Pagnesi, Filippo Calì, Mauro Chiarito, Davide Stolfo, Luca Baldetti, Carlo M. Lombardi, Daniela Tomasoni, Ferdinando Loiacono, Marta Maccallini, Alessandro Villaschi, Daniele Cocianni, Maria Perotto, Adriaan A. Voors, Daniela Pini, Marco Metra, Marianna Adamo, HELP-HF Registry investigators

Mitral regurgitation (MR) is the most common valvular heart disease in patients with heart failure (HF) [1]. Left ventricular remodeling, left atrial enlargement, and cardiac dyssynchrony leading to... more

Risk of subclinical atherosclerosis in primary Sjogren's syndrome: A systematic review and meta-analysis

15 November 2023
Author(s): Paschalis Karakasis, Dimitrios Patoulias, Konstantinos Pamporis, Panagiotis Stachteas, Eleftheria Lefkou, Konstantinos I. Bougioukas, Theodoros Dimitroulas, Nikolaos Fragakis

Cardiovascular disease (CVD) in systemic autoimmune disorders often goes unnoticed until a clinical event occurs. Given the lack of disease-specific prediction scores, the CVD risk stratification... more

Calprotectin serum levels on admission and during follow-up predict severity and outcome of patients with COVID-19: A prospective study

10 November 2023
Author(s): Nikolaos K. Gatselis, Aggeliki Lyberopoulou, Vasiliki Lygoura, George Giannoulis, Anna Samakidou, Antonia Vaiou, Katerina Antoniou, Katerina Triantafyllou, Aggelos Stefos, Sarah Georgiadou, Dimitrios Sagris, Dafni Sveroni, Stella Gabeta, George Ntaios, Gary L. Norman, George N. Dalekos

Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by a broad spectrum of clinical manifestations [1]. SARS-CoV-2... more

Prognostic significance of the wall to lumen ratio of retinal arterioles evaluated by adaptive optics

31 October 2023
Author(s): Carolina De Ciuceis, Claudia Agabiti Rosei, Paolo Malerba, Claudia Rossini, Matteo Nardin, Giulia Chiarini, Francesca Famà, Matteo Lemoli, Mattia Baresi, Alina Petelca, Chiara Bortoluzzi, Enzo Porteri, Massimo Salvetti, Maria Lorenza Muiesan, Enrico Agabiti Rosei, Damiano Rizzoni

The main characteristic of essential hypertension is the increase in peripheral vascular resistance to blood flow, located mostly in small arteries with a lumen diameter of 100 to 350 μm and in... more

ECG/echo indexes in the diagnostic approach to amyloid cardiomyopathy: A head-to-head comparison from the AC-TIVE study

17 October 2023
Author(s): Linda Pagura, Aldostefano Porcari, Matteo Cameli, Elena Biagini, Marco Canepa, Lia Crotti, Massimo Imazio, Cinzia Forleo, Rita Pavasini, Giuseppe Limongelli, Stefano Perlini, Marco Metra, Giuseppe Boriani, Michele Emdin, Gianfranco Sinagra, Marco Merlo, ACTIVE study group

Thickened left ventricle (LV) is the hallmark of amyloid cardiomyopathy (AC) and results from progressive amyloid deposition in the myocardial extracellular space rather than myocyte hypertrophy [1... more

Review Article

Single-pill combination for treatment of hypertension: Just a matter of practicality or is there a real clinical benefit?

22 April 2024
Author(s): A Coca, SP Whelton, M Camafort, JP López-López, E Yang

Cardiovascular disease (CVD) represents the leading cause of morbidity and mortality worldwide resulting in approximately one third of all deaths globally [1,2]. Despite significant advances in... more

Type 1 diabetes-related distress: Current implications in care

11 April 2024
Author(s): Alba Rodríguez-Muñoz, María José Picón-César, Francisco J. Tinahones, José Ignacio Martínez-Montoro

Type 1 diabetes (T1D) is a complex and demanding chronic disease characterized by a severe lack of insulin synthesis which needs to be supplied exogenously [1,2]. In this context, people living with... more

Metabolic Bariatric surgery in People with Obesity aged ≥65 Years

30 March 2024
Author(s): Nursel Çalık Başaran, Dana Marcoviciu, Dror Dicker

The World Health Organization (WHO) estimated that 1.4 billion people in the world will be aged 60 years and older in 2030 and 2.1 billion by 2050, comprising 12–22 % of the global population [1].... more

Gender-specific insights into the irritable bowel syndrome pathophysiology. Focus on gut dysbiosis and permeability

10 March 2024
Author(s): Jerlin Stephy JohnBritto, Agostino Di Ciaula, Antonino Noto, Velia Cassano, Angela Sciacqua, Mohamad Khalil, Piero Portincasa, Leonilde Bonfrate

Irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder, manifests through recurrent episodes of abdominal pain or discomfort, coupled with variations in bowel habits... more

The complement system in the pathogenesis and progression of kidney diseases: What doesn't kill you makes you older

8 March 2024
Author(s): Emma Diletta Stea, Giuseppina D'Ettorre, Adele Mitrotti, Loreto Gesualdo

The Complement System is an evolutionarily conserved component of immunity that plays a key role in host defense against infections and tissue homeostasis. However, the dysfunction of the Complement... more

Challenges of antimicrobial stewardship among older adults

14 February 2024
Author(s): Joana Alves, Virginie Prendki, Marie Chedid, Dafna Yahav, Davide Bosetti, Jordi Rello, ESCMID Study group of infections in the elderly (ESGIE)

Antimicrobial resistance is a global public health concern that threatens our ability to treat bacterial infections successfully [1]. Whereas antimicrobial optimization in the hospital was reported... more

Treatment in primary biliary cholangitis: Beyond ursodeoxycholic acid

2 February 2024
Author(s): M.C. van Hooff, E. Werner, A.J. van der Meer

Primary biliary cholangitis (PBC), which was formerly called primary biliary cirrhosis, is a rare chronic immune-mediated liver disease [1,2]. A recent meta-analysis indicated that the pooled global... more

Dietary and pharmacological treatment in patients with metabolic-dysfunction associated steatotic liver disease

22 January 2024
Author(s): Angelo Armandi, Elisabetta Bugianesi

Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic Fatty Liver Disease, is a spectrum of liver injury characterized by increased hepatocellular fat... more

Non-invasive testing and risk-stratification in patients with MASLD

20 January 2024
Author(s): Mirko Zoncapè, Antonio Liguori, Emmanuel A. Tsochatzis

The development and validation of non-invasive fibrosis tests (NITs) has changed clinical practice in Hepatology over the last 15 years. Metabolic associated steatotic liver disease (MASLD), formerly... more

The impact of colchicine on patients with acute and chronic coronary artery disease

17 January 2024
Author(s): Mehdi Madanchi, Mabelle Young, Gregorio Tersalvi, Giacomo Maria Cioffi, Adrian Attinger-Toller, Florim Cuculi, Reto Kurmann, Matthias Bossard

Inflammation is a major contributor in the development and progression of coronary artery disease (CAD). Preclinical studies have demonstrated that inflammatory processes, by means of specific... more

Resistant hypertension: Diagnosis, evaluation, and treatment practical approach

15 January 2024
Author(s): Roberto Parodi, Laura Brandani, César Romero, Manuel Klein

Our learning objectives are to be able to identify patients with resistant hypertension (RH) in primary care practice, know the clinical and phenotypic characteristics of this group of patients, and... more

Breakthrough advances enhancing care in ATTR amyloid cardiomyopathy

5 January 2024
Author(s): Aldostefano Porcari, Gianfranco Sinagra, Julian D Gillmore, Marianna Fontana, Philip N Hawkins

Transthyretin amyloid cardiomyopathy (ATTR-CM) has been traditionally considered a rare and inexorably fatal condition. ATTR-CM now is an increasingly recognized cause of heart failure (HF) and... more

Enduring echoes: Post-infectious long-term changes in innate immunity

21 December 2023
Author(s): Elisabeth A. Dulfer, Leo A.B. Joosten, Mihai G. Netea

The human immune system is one of the main host defence mechanism against infections, initiating a complex response when confronted with pathogenic invaders. This response involves pathogen... more

Natural history of metabolic dysfunction-associated steatotic liver disease

6 November 2023
Author(s): Vasileios Lekakis, George V. Papatheodoridis

Metabolic dysfunction-associated steatotic liver disease (MASLD) has been the term for non-alcoholic fatty liver disease (NAFLD) since June 2023 and will be used instead of NAFLD throughout this... more


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