Should we look for anti-RNA polymerase III antibodies in systemic sclerosis patients with anti-centromere or anti-topoisomerase I antibodies?

Systemic sclerosis (SSc) is a chronic autoimmune disease characterised by skin and internal organs fibrosis, vascular damage and positive antinuclear autoantibodies (ANAs). The classical antigenic specificities of ANAs are anti-centromere (ACA), anti-topoisomerase I antibodies (anti-topo I) and the more recently described anti-RNA polymerase III antibodies (anti-RNAPIII).