A 23 years old female patient presented to clinical hematology consultation with asthenia and mild bilateral femoral pain. She has a history of anemia without clear etiology during her childhood. Physical examination showed pallor without icterus and a splenomegaly, 14 cm below the left costal margin. There was no hepatomegaly and no peripheral lymphadenopathy. Complete blood count revealed a microcytic anemia (hemoglobin, 8 g/dL; reference range 12 to 16, median corpuscular volume, 72 fL) and thrombocytopenia (platelet count, 70,000 per microliter; reference range 140,000 to 400,000).
