A 64-year-old-man, with history of hypertension, dyslipidemia, serous chorioretinopathy and past-smoking history (15 pack-years) presented with asthenia and weight loss (6 kg in 6 months). His-physical examination was unremarkable and biological tests showed inflammation (CRP 20 mg/L). A retroperitoneal fibrosis was diagnosed on CT-scan with a left pulmonary nodule and mediastinal lymphadenopathy (Fig 1. A, B), these lesions being hypermetabolic on PET-scan. A lung nodule biopsy showed no malignant cells, but fibrosis associated with a lymphocytic infiltration.