Sarcoidosis is a systemic granulomatous disease associated with T lymphocyte and macrophage activation and migration into affected organs. The interaction between antigens and antigen-presenting cells polarizes T lymphocytes to the T helper 1 phenotype (Th1), leading to the formation of sarcoid granulomas consisting of T cells, macrophages, epithelioid and giant cells [1]. The course of sarcoidosis is unpredictable: remission occurs in most cases, while persistent granuloma inflammation may lead to fibrotic lung disease [2, 3].
