Published: 20 May 2021
Author(s): Mark F.J. Stolk, Aad P. van den Berg, Karel J. van Erpecum
Issue: August 2021
Section: Commentary

Autoimmune hepatitis (AIH) is a rare and challenging disease. Its presentation ranges from mildly elevated transaminases to jaundice with decompensated liver disease. Blood tests often reveal elevated immunoglobulin G levels and several antibody tests like anti-smooth muscle antibodies, liver-kidney microsomal antibodies or soluble liver antigen antibodies can be positive. Viral hepatitis (including hepatitis E viral infection), drug-induced liver injury and (especially in young patients) Wilson disease should be excluded.

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