December 2018
17 ArticlesNo Section
Nipple shadows
A 49-year-old female was being followed-up for malignant melanoma after surgery. Six months earlier, she had undergone amputation of right 4th finger and sentinel lymph node biopsy. A medical history... more
Computerized algorithms compared with a nephrologist's diagnosis of acute kidney injury in the emergency department
The aim of this study was to examine acute kidney injury (AKI) diagnosis based on different computerized algorithms compared with a nephrologist's diagnosis in patients visiting an emergency... more
Bringing complexity into clinical practice: An internistic approach
Modern medicine, still largely focused on single diseases, is unprepared for managing clinical complexity (CC), which is an emerging issue. Ageing of the general population has favoured the... more
Management of celiac disease in daily clinical practice
Celiac disease (CD) is the most common autoimmune enteropathy worldwide. In CD, dietary gluten triggers a T cell driven small intestinal inflammation in a subset of genetically predisposed subjects,... more
Chemotherapy-free and reduced intensity approaches in elderly patients with B-lineage acute lymphoblastic leukemia
Management of older patients - defined by convention above the age of 60 years, but varying widely within study groups - with acute lymphoblastic leukemia (ALL) is still a challenge. The complete... more
Myelodysplastic syndromes and acute myeloid leukemias in the elderly
Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with myelodysplastic syndromes (MDS) and AML are... more
Management of unfit elderly patients with chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a disease characterized by an increasing incidence with age reaching 35/100,000 in patients over 85 years. Elderly CLL patients carry several challenges, which... more
Antipsychotics and severe hyponatremia: A Swedish population–based case–control study
Antipsychotics have been claimed to cause hyponatremia. The risk associated with individual antipsychotics, or groups (first-generation [FGAs] or second-generation [SGAs] antipsychotics), is not well... more
Internal Medicine Flashcard
A young woman with left lower chest pain
A 34-years old woman presented to the emergency department with complaints of acute-onset and progressive left upper quadrant abdominal and left lower chest pain, nausea, and fever since about 4 days... more
Atypical rash
A 42-year-old hypothyroid woman, who lived her entire life in a rural place of Colombia, used to hunt and eat Armadillo over several years when she was a child, and now presented to the emergency... more
Invited Article
Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly
The physiology of the immune system involves morphologic and functional changes occurring along ageing, with a decrease in immune response and an increase in autoimmune phenomena, even in the absence... more
Special problems in the management of elderly patients with multiple myeloma
Multiple myeloma (MM) is a neoplastic disease typical of the elderly. Many steps forward have been made in the characterization of patients, and new treatment strategies are available today. Clinical... more
Letter to the Editor
Risk of hypoglycemia in hospitalized patients with diabetes mellitus
We read with interest the review article by Yosefa Bar-Dayan et al., “Hypoglycemia-simplifying the ways to predict an old problem in the general ward” that has been published online in the European... more
Management of celiac disease in daily clinical practice: do not forget depression!
Sir,
Original Article
Multimorbidity in middle age predicts more subsequent hospital admissions than in older age: A nine-year retrospective cohort study of 121,188 discharged in-patients
Previous research has suggested a differential short-term effect of multimorbidity on hospitalization by age, with younger groups affected more. This study compares the nine-year hospitalization... more
Impact of anemia as risk factor for major bleeding and mortality in patients with acute coronary syndrome
Anemia is frequent in acute coronary syndrome (ACS) patients and is associated with worse clinical outcomes. We aimed to investigate the therapeutic strategies, the use of novel P2Y12 inhibitors, and... more
Mortality rate and risk factors for gastrointestinal bleeding in elderly patients
Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB... more