Conway et al. performed a retrospective study using administrative data to assess the utility of two parameters to predict 30-day mortality during an emergency department (ED) visit [1]. They evaluated the potential prognostic roles of a newly developed Comorbidity Index that assess patient comorbidities, and an Acute Illness Severity Score (AISS) that quantifies the severity of the present illness. The authors stratified mortality risk, and correlated the severity of the acute disease and the comorbidity burden to clinical outcomes.