Published: 4 December 2019
Author(s): Bhagwan Dass, Thomas M. Beaver, Michiko Shimada, Kawther F. Alquadan, Abhilash Koratala, Girish Singhania, Amardeep Singh, A. Ahsan Ejaz
Section: Review Article

In 1981, de Bold reported that injection of supernatants of atrial and ventricular myocardial homogenates into rats resulted in 30-fold increase of sodium and chloride excretions and 10-fold increase in urine volume [1]. This landmark discovery of atrial natriuretic peptides (ANP) was followed by characterization of B-type/Brain (BNP), C-type (CNP), Dendroaspis (DNP) and urodilantin (URO) natriuretic peptides (NP). NP have a highly preserved 17-amino acid (aa) cyclic structure constructed with disulfide bond.

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