For the last 20 years multi-resistant strains have changed the paradigm of in-hospital antibiotic prescription, forcing physicians to prescribe more broad-spectrum antibiotics. This selective pressure drives the emergence of new mechanisms of resistance, reducing our therapeutic arsenal [1]. This concept has shifted of rational antibiotic prescription towards the duration of antibiotic cycles [2]. Both microbiological studies of bacterial population dynamics and studies regarding mechanisms of acquired resistance appear to favor shorter durations of therapy [3,4].
