In patients with acute symptomatic pulmonary embolism (PE), the presence of concomitant lower-limb deep vein thrombosis (DVT) has been identified as an independent predictor of death [1–5]. The mechanism to justify this association is still unknown. The coexistence of DVT in published series of PE patients ranges from 44% to 71%, according to whether the tests to detect DVT were systematically performed, or only in patients with DVT symptoms [1–3,6–8]. Interestingly, only 42% to 51% of PE patients and concomitant lower-limb DVT complain of DVT symptoms in the literature [1,3,6].