Adherence to treatment poses two challenges. First, identifying patients who are non-compliant to treatments. Secondly, improving adherence. The issue of adherence has been addressed in this issue of the European Journal of Internal Medicine by two eminent experts in the field. Burnier highlighted how poor adherence to treatments encompasses both symptomatic and asymptomatic diseases, and this intricate dynamic often prompts additional therapeutic interventions under the assumption of treatment resistance, as exemplified in conditions like arterial hypertension [1].