January 2017

27 Articles

No Section

Characterization of the medical admissions in a tertiary Greek hospital

23 January 2017
Author(s): Irene Eliadi, Georgia Tsoumi, Olga Kampouropoulou, Vasileios Theofanis, Marina Mantzourani, Michael Samarkos

From 2009 to 2013 the number of admissions for the 1st Health District, which includes the majority of hospitals in Athens, Greece, has increased by 33.1% while the expenditure was reduced by 31.1%... more

Why modern internists should be also researchers?

20 January 2017
Author(s): Marco Zuin, Gianluca Rigatelli, Giuseppe Del Favero, Loris Roncon

Internal Medicine has drastically changed over the last years. Similarly, medical education has undergone significant changes, especially after the introduction of simulation- based medical teaching... more


Depression significantly reduces the 6-minute walking distance in systolic heart failure: Insights from the ESCAPE trial

26 January 2017
Author(s): Hesham R. Omar, Maya Guglin

Over the past two decades, there has been an increased interest to study the relationship between depression and heart failure (HF) stemming from the fact that HF is the fastest growing entity of... more


Defining a care pathway for patients with multimorbidity or frailty

19 January 2017
Author(s): Graziano Onder, Matteo Cesari, Marcello Maggio, Katie Palmer

Multimorbidity and frailty are highly prevalent and emerging conditions [1–5]. Contrary to patients' and primary care providers' perceptions [6], multimorbidity does not necessarily imply the onset... more

Internal Medicine Flashcard

A bifid albumin peak of recent onset

23 January 2017
Author(s): C. Bachmeyer, S. Georgin-Lavialle

A previously healthy 29-year-old woman was admitted to the hospital for dyspnea, fever at 39°C, arthralgia and myalgia. She had been treated one month before for a first episode of pneumonia treated... more

A case of tracheobronchomegaly

18 January 2017
Author(s): Jirat Chenbhanich, Juan Villa-Camacho, Jason Konter

Tracheobronchomegaly (Mounier-Kuhn syndrome) is a rare condition characterized by an abnormally enlarged trachea and main bronchi. Herein, we present a case of 79-year-old male with idiopathic... more

Letter to the Editor

In-hospital mortality and diabetes: Absence of association

31 January 2017
Author(s): Francesco Cei, Daniela Cannistraro, Nicola Mumoli, Marco Cei

Diabetes and hyperglycemia are commonly considered in-hospital mortality determinants, as shown by the retrospective analysis of Umpierrez [1] and Krinsley [2]. However, we already found these... more

Who to screen for CALR mutations? An audit of real-life practice and review of current evidence

26 January 2017
Author(s): Karl Haslam, Stephen E. Langabeer

The myeloproliferative neoplasms (MPN) are clonal, hematopoietic stem cell-derived diseases characterised by bone marrow proliferation of one or more of the myeloid cell lineages with the main... more

Peer reviewing and Editor's decision should never be a personal conflicting matter

24 January 2017
Author(s): Salvatore Chirumbolo

I came through the latest paper on the journal by Napolitani et al., about peer reviewing of scientific reports in the academic community of experts [1]. I joined the Editorial Board as a Member of... more

Acute medical units, more capacity without increasing resources

17 January 2017
Author(s): Eleonora M. Schipper

My compliments on the review of van Galen et al. [1] concerning implementation of acute medical care units in the Netherlands. It was no easy task to investigate this diversity in wards and articles.

New-onset atrial fibrillation after percutaneous coronary intervention with stent: Updated proposal of an algorithm for the choice of oral anticoagulant and its dose

10 January 2017
Author(s): Andrea Rubboli, Stefan Agewall, Kurt Huber, Gregory Y.H. Lip

Whereas ongoing oral anticoagulation (OAC), with either warfarin or a non-vitamin K-antagonist oral anticoagulant (NOAC), should generally be confirmed in patients with atrial fibrillation (AF) who... more

Obstructive sleep apnoea, type 2 diabetes and cardiovascular risk factors

9 January 2017
Author(s): B. De Vega Sánchez, S.A. Juarros Martínez, Milagros Del Olmo Chiches, C. Disdier Vicente, E. González Sarmiento

Obstructive sleep apnea (OSA), characterized by episodes of upper airway collapses and sleep fragmentation, is the most prevalent sleep-breathing-disorder. Recent researches suggest the overall... more

The problem with incidental and chronic portal vein thrombosis

8 January 2017
Author(s): Mohammad Haris, Jecko Thachil

Thrombosis in the portal vein (PVT) can occur at any point along its course from the junction of the splenic vein and the superior mesenteric vein [1]. Classically, PVT is described to present with... more

Anonymous biomedical publications for security reason? An open letter to the ICJME

7 January 2017
Author(s): P Charlier, S Deo, C Hervé

Can we publish anonymously in a biomedical journal for security reasons?

The longitudinal relationship between six-minute walk test and cardiopulmonary exercise testing, and association with symptoms in systolic heart failure: Analysis from the ESCAPE trial

5 January 2017
Author(s): Hesham R. Omar, Maya Guglin

The six-minute walk test (6MWT) and cardiopulmonary exercise testing (CPET) are two objective modalities utilized for examining the functional status in patients with heart failure (HF). CPET... more

Periodic dosing regimens of atorvastatin and rosuvastatin for dyslipidemia: A systematic review and meta-analysis of randomized controlled trials

4 January 2017
Author(s): Kannan Sridharan, Gowri Sivaramakrishnan

Statins constitute the major class of cholesterol-lowering drugs and 10–15% reported Statin induced myalgia [1]. Randomized controlled trials report that alternate day or once a week dosing of long... more

Letters to the Editor

Pulmonary arterial hypertension associated with connective tissue disease: Insights from Latvian PAH registry

17 January 2017
Author(s): Andris Skride, Kristaps Sablinskis, Yuval Avidan, Ainars Rudzitis, Aivars Lejnieks

The term connective tissue disease (CTD) refers to a group of autoimmune disorders that are classified among the systemic rheumatic diseases [1]. Pulmonary arterial hypertension (PAH) is a common and... more

Narrative Review

Hot heads & cool bodies: The conundrums of human BAT activity research

5 January 2017
Author(s): Lonneke Bahler, Frits Holleman, Jan Booij, Joost B. Hoekstra, Hein J. Verberne

Brown adipose tissue is able to increase energy expenditure by converting glucose and fatty acids into heat. Therefore, BAT is able to increase energy expenditure and could thereby facilitate weight... more

Original Article

Incidence, characteristic and outcomes of ventilator-associated pneumonia among type 2 diabetes patients: An observational population-based study in Spain

27 January 2017
Author(s): Isabel Jiménez-Trujillo, Rodrigo Jiménez-García, Javier de Miguel-Díez, José M. de Miguel-Yanes, Valentín Hernández-Barrera, Manuel Méndez-Bailón, Napoleón Pérez-Farinós, Miguel-Ángel Salinero-Fort, Ana López-de-Andrés

To describe incidence, characteristics and outcomes of ventilator-associated pneumonia (VAP) during hospitalization among patients with or without type 2 diabetes (T2DM).

The effect of a short-stay unit on hospital admission and length of stay in acute heart failure: REDUCE-AHF study

23 January 2017
Author(s): Òscar Miró, Virginia Carbajosa, W. Frank Peacock, Pere Llorens, Pablo Herrero, Javier Jacob, Sean P. Collins, Cristina Fernández, Antoni Juan Pastor, Francisco Javier Martín-Sánchez, on behalf of the ICA-SEMES group

To determine whether the presence of a short-stay unit(SSU) in a hospital influences the percentage of admissions, length of hospital stay(LOS) and outcomes in emergency department(ED) patients with... more

The TSH levels and risk of hypothyroidism: Results from a population based prospective cohort study in an Iranian adult's population

19 January 2017
Author(s): Ashraf Aminorroaya, Rokhsareh Meamar, Massoud Amini, Awat Feizi, Maryam Nasri, Azamosadat Tabatabaei, Elham Faghihimani

The aim of current study was to assess the relationship between serum TSH levels and hypothyroidism risk in the euthyroid population.

COMP serum levels: A new non-invasive biomarker of liver fibrosis in patients with chronic viral hepatitis

15 January 2017
Author(s): Kalliopi Zachou, Stella Gabeta, Zakera Shums, Nikolaos K. Gatselis, George K. Koukoulis, Gary L. Norman, George N. Dalekos

Recently we have shown that cartilage oligomeric matrix protein (COMP), a fibrillar collagen assembly regulator, is strongly associated with cirrhosis and hepatocellular carcinoma progression.... more

Time trends in incidence and outcomes of hospitalizations for aspiration pneumonia among elderly people in Spain (2003−2013)

5 January 2017
Author(s): Domingo Palacios-Ceña, Valentín Hernández-Barrera, Ana López-de-Andrés, César Fernández-de-las-Peñas, María Palacios-Ceña, Javier de Miguel-Díez, Pilar Carrasco-Garrido, Rodrigo Jiménez-García

Aspiration pneumonia (AP) is an infectious process causing high rates of mortality. The purpose of this study was: 1, to describe the incidence from 2003 to 2013 of AP hospitalizations; 2, to assess... more

Reflections in Internal Medicine

Generalism in modern subspecializing medicine

5 January 2017
Author(s): Marcel Levi

Medicine is currently developing at a breath holding pace. Diseases and medical conditions for which no remedy was available only a few years ago, can now be treated or even completely cured. However... more

Review Article

Antithrombotic treatment in anticoagulated atrial fibrillation patients undergoing percutaneous coronary intervention

6 January 2017
Author(s): Csaba András Dézsi, Balázs Bence Dézsi, Döme András Dézsi

Coronary artery disease coexists in a clinically relevant number of patients with atrial fibrillation and it often requires percutaneous coronary intervention. These patients represent a particular... more

Deprescribing: A narrative review of the evidence and practical recommendations for recognizing opportunities and taking action

5 January 2017
Author(s): Emily Reeve, Wade Thompson, Barbara Farrell

Deprescribing can be defined as the process of withdrawal or dose reduction of medications which are considered inappropriate in an individual. The aim of this narrative review is to provide an... more


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