A 48-year-old man presented at our hospital with worsening edema of the lower limbs. He had been suffering from lower limb lymphedema, recurrent erysipelas infections, and disseminated warts since childhood, for which he had already undergone Lymphovenous Microsurgery, however, with poor efficacy. Further medical history was insignificant. The patient was asymptomatic, apart from mobilization and wound healing difficulties. Clinical examination showed lower limb lymphedema with papillomatosis and some pitting [Fig.