Migraine continues to be the 6th most disabling illness with extremely incapacitating neurological symptoms affecting approximately 39 millions of US population. Besides its chronic illness, migraine impacts a significant economic burden with billions spent each year on medical services. American employers lose more than $13 billion each year as a result of 113 million lost work days due to a migraine. Apart from its burden of a migraine attack itself, migraine increases the risk for other physical and psychiatric conditions [1].